Relationship between the humoral link of immunity, cytokine regulation with short-chain fatty acids in patients with inflammatory bowel diseases




shortchain fatty acids, humoral immunity, cytokines, ulcerative colitis, Crohn’s disease


Background. The pathogenesis of chronic inflammatory bowel disease (IBD) is still not fully clarified. Modern research is aimed at studying the state of humoral immunity, production and intestinal absorption of short-chain fatty acids (SCFA). The purpose was to assess the state of the humoral part of immunity, cytokine regulation and the content of short-chain fatty acids in the feces of patients with IBD. Materials and methods. The study, which was carried out at the Department of Intestinal Diseases of the Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine, involved 34 patients with IBD: group I — those with ulcerative colitis (UC) (n = 25), group II — individuals with Crohn’s disease (n = 9). Determination of fecal SCFA, level of CD22+ lymphocytes, immunoglobulins A, M, G, interleukin-10 and TNF-α was determined. Results. There was a decrease in the humoral level of immunity, increase in the content of propionic (C3) acid (p < 0.001) and a decrease in acetic (C2) (p < 0.001) and butyric (C4) (p < 0.001) acids in the coprofiltrate of patients with IBD. The level of TNF-α was significantly higher in patients with mild UC (13.3 times, p < 0.05), in patients with moderate UC (17.4 times, p < 0.05) and in patients with Severe UC (19.4 times, p < 0.05) compared with its level in the control group; it was found that in the group of patients with severe UC there was a significant decrease in the content of butyric acid (C4) in 2.8 times relative to the control group (p < 0,01). Conclusions. In our study, a relationship was established between the level of humoral immunity, cytokine regulation and the content of FFA in feces, which may indicate the participation of intestinal metabolites in the activation of human immunity.


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How to Cite

Stepanov, Y., Stoikevych, M., Klenina, I., & Tatarchuk, O. (2022). Relationship between the humoral link of immunity, cytokine regulation with short-chain fatty acids in patients with inflammatory bowel diseases. GASTROENTEROLOGY, 56(2), 103–109.



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