Changes in serum somatostatin level and its association with calcium metabolism indicators in patients with gastroesophageal reflux disease and spinal injuries of degenerative-dystrophic and inflammatory genesis
Keywords:esophageal, extraesophageal manifestations of gastroesophageal reflux disease, osteochondrosis, spondyloarthritis, somatostatin, vitamin D3, calcium
Background. The study of clinical features, factors and levels of various biologically active substances that may play an important role in the pathogenetic mechanism of gastroesophageal reflux disease (GERD) in combination with degenerative-dystrophic or inflammatory lesions of the spine, is an extremely important problem of the modern medical community. The purpose of the research is to determine the peculiarities of changes in the level of serum somatostatin (SST) and its relationship with calcium metabolism in patients with GERD and spine lesions of degenerative-dystrophic and inflammatory genesis. Materials and methods. 84 patients with spinal lesions of degenerative-dystrophic or inflammatory genesis in combination with GERD were examined. The examined patients with GERD were divided into two groups depending on the form of spine injury. Group I included 44 patients with osteochondrosis (OS) of the cervical and thoracic spine (SpA). Group II consisted of 40 patients with spinal arthritis. Results. There was a significant increase in the level of serum SST in both groups of the studied patients with GERD and spine injury of degenerative-dystrophic or inflammatory origin. At the same time, a more pronounced deviation from the norm was detected in group II of patients (increase up to (0.756 ± 0.027) pg/ml, p < 0.01). Determination of level 25(OH)D in serum indicates vitamin D3 deficiency in patients with GERD and OS (decrease to (23.35 ± 0.71) ng/ml, p < 0.05) and its deficiency in patients with SpA (decrease to (18.66 ± 0.52) ng/ml, p < 0.01). Serum 25(OH)D levels also decreased more markedly in the atypical clinical course of GERD in the examined patients. Conclusions. In patients with GERD with degenerative-dystrophic and inflammatory lesions of the spine, an increase in the level of serum SST was found with the most pronounced deviation from the norm in atypical manifestation of GERD. A correlation between SST and a decrease in the level of 25(OH)D and Ca++, mainly in patients with atypical clinical course of GERD, was established.
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