Changes in serum somatostatin level and its association with calcium metabolism indicators in patients with gastroesophageal reflux disease and spinal injuries of degenerative-dystrophic and inflammatory genesis

Authors

DOI:

https://doi.org/10.22141/2308-2097.56.1.2022.481

Keywords:

esophageal, extraesophageal manifestations of gastroesophageal reflux disease, osteochondrosis, spondyloarthritis, somatostatin, vitamin D3, calcium

Abstract

Background. The study of clinical features, factors and levels of various biologically active substances that may play an important role in the pathogenetic mechanism of gastroesophageal reflux disease (GERD) in combination with degenerative-dystrophic or inflammatory lesions of the spine, is an extremely important problem of the modern medical community. The purpose of the research is to determine the peculiarities of changes in the level of serum somatostatin (SST) and its relationship with calcium metabolism in patients with GERD and spine lesions of degenerative-dystrophic and inflammatory genesis. Materials and methods. 84 patients with spinal lesions of degenerative-dystrophic or inflammatory genesis in combination with GERD were examined. The examined patients with GERD were divided into two groups depending on the form of spine injury. Group I included 44 patients with osteochondrosis (OS) of the cervical and thoracic spine (SpA). Group II consisted of 40 patients with spinal arthritis. Results. There was a significant increase in the level of serum SST in both groups of the studied patients with GERD and spine injury of degenerative-dystrophic or inflammatory origin. At the same time, a more pronounced deviation from the norm was detected in group II of patients (increase up to (0.756 ± 0.027) pg/ml, p < 0.01). Determination of level 25(OH)D in serum indicates vitamin D3 deficiency in patients with GERD and OS (decrease to (23.35 ± 0.71) ng/ml, p < 0.05) and its deficiency in patients with SpA (decrease to (18.66 ± 0.52) ng/ml, p < 0.01). Serum 25(OH)D levels also decreased more markedly in the atypical clinical course of GERD in the examined patients. Conclusions. In patients with GERD with degenerative-dystrophic and inflammatory lesions of the spine, an increase in the level of serum SST was found with the most pronounced deviation from the norm in atypical manifestation of GERD. A correlation between SST and a decrease in the level of 25(OH)D and Ca++, mainly in patients with atypical clinical course of GERD, was established.

Downloads

Download data is not yet available.

References

Svyrydova NK, Sereda VG, Popov AV, Pavlyuk NP, Svystun VY, Usovych KM. Clinical and functional status of the peripheral nervous system in patients with diabetic polyneuropathy. East Europen Journal of Neurology. 2015;02(02):14-26. (in Ukrainian).

Shostak NA. Seronegative spondyloarthropathies – new options in the diagnosis and treatment. Consilium medicum. 2014;16(12):32-34. (in Russian).

Babinets LS, Halabitska IM. Evaluation of pancreatotropic and joint efficiency of intracellular systemic enzyme in osteoarthritis. Family medicine. 2020;(91-92):66-69. (in Ukrainian).

Konkova LA, Konkov AV. Gastroesophageal reflux: extra-oesophageal manifestations. Medical Bulletin of the Ministry of Internal Affairs. 2016;(81):247-50. (in Russian).

Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013 Mar;108(3):308-28; quiz 329. doi: 10.1038/ajg.2012.444.

Sviridova TN, Alekseev NYu, Kozlov YuS. Gastroesophageal reflux disease. Voronezh; 2009. 69 р. (in Russian).

Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999 Aug;45(2):172-80. doi: 10.1136/gut.45.2.172.

Nasonov YeL. The 2016 EULAT guidelines for the diagnosis and treatment of early arthritis. Nauchno-prakticheskaya revmatologiya. 2017;55(2):138-150. doi: 10.14412/1995-4484-2017-138-150. (in Russian).

WHO. Global Recommendations on Physical Activity for Health. 2011. Available from: http://whqlibdoc.who.int/publications/2010/9789241599979_eng.pdf.

Boichuk V. The role of pepsinogenes and some intestinal hormones in pathogenesis of gastroesophageal reflux disease. EUREKA: Health Sciences. 2018;(1):3-8. doi: 10.21303/2504-5679.2018.00538..

Chen J, Guo B, Guo Z, et al. Association of serum gastric inhibitory polypeptide and pancreatic polypeptide levels with prolonged esophageal acid exposure time in refractory gastroesophageal reflux disease. Medicine (Baltimore). 2019 Jun;98(23):e15965. doi: 10.1097/MD.0000000000015965.

Sans, MD, Bruce, J, and Williams, JA. Regulation of Pancreatic Exocrine Function by Islet Hormones. Pancreapedia: Exocrine Pancreas Knowledge Base. 2020. doi: 10.3998/panc.2020.01.

Silve C, Lieberherr M, Garabedian M, et al. Somatostatin and vitamin D3 metabolites in rat calvarium: in vitro evidence for physiological interaction. Endocrinology. 1981 Nov;109(5):1454-62. doi: 10.1210/endo-109-5-1454.

Ajmal A, Haghshenas A, Attarian S, Barake M, Tritos NA, Klibanski A, Miller KK, Nachtigall LB. The effect of somatostatin analogs on vitamin D and calcium concentrations in patients with acromegaly. Pituitary. 2014 Aug;17(4):366-73. doi: 10.1007/s11102-013-0514-0.

Downloads

Published

2022-05-09

How to Cite

Szircsak, Y., Tsoka, S., & Filak, Y. (2022). Changes in serum somatostatin level and its association with calcium metabolism indicators in patients with gastroesophageal reflux disease and spinal injuries of degenerative-dystrophic and inflammatory genesis. GASTROENTEROLOGY, 56(1), 8–13. https://doi.org/10.22141/2308-2097.56.1.2022.481

Issue

Section

Original Researches