Peculiarities of the relationship between aggressive and protective factors of the gastric mucosa in patients with esophagogastroduodenal pathology with impaired adaptive potential and autonomic homeostasis (according to PRECISE-diagnostics)

Authors

  • B.F. Shevchenko State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine
  • N.V. Prolom State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine
  • E.V. Zyhalo State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine https://orcid.org/0000-0001-5026-0992
  • A.I. Rudenko State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine
  • L.V. Demeshkina State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine https://orcid.org/0000-0002-7301-1857
  • R.M. Kyslova State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine

DOI:

https://doi.org/10.22141/2308-2097.55.4.2021.247912

Keywords:

aggressive and protective factors, gastric mucosa, autonomic tone, adaptive potential, heart rate variability, esophagogastroduodenal zone

Abstract

Background. An imbalance of interaction between the sympathetic and parasympathetic links of the autonomic nervous system leads to autonomic dysregulation of the heart rate resulting in insufficient stress resistance, impaired adaptation and depletion of the protective mechanisms of the gastric mucosa. Therefore, the purpose of our research was to study adaptive potential of the body depending on the aggressive and protective factors of the gastric juice. Materials and methods. Seventy-one patients with esophagogastroduodenal pathology were examined using the method of PRECISE-diagnostics. The level of pH, pepsin, glycoproteins, fucose and sialic acids in the gastric contents was determined. The patients were divided into 3 representative groups: I — 30 individuals with hiatal hernia; II — 20 patients with achalasia cardia; III — 21 people with duodenal ulcer disease complicated by stenosis. Results. An imbalance of sympathetic and parasympathetic links of autonomic system was detected in 85.2 % of patients. The sympathetic mechanisms dominated in 71.3 % of cases. At the same time, most patients with achalasia cardia had vagotonia. The adaptive and compensatory mechanisms were identified after studying the relationship between the aggressive and protective factors of the gastric mucosa. When analyzing the correlation of aggressive and protective factors of gastric juice, the following adaptive and compensatory options were revealed: 1) hyperreactive, with simultaneous increase in the factors of both aggression and protection; 2) compensatory (an increase in the level of aggressive factors against the background of normal protective indicators); 3) decompensatory (an increase in the level of aggressive factors simultaneously with a decrease in protective factors). Conclusions. The adaptive potential of the body in 85.2 % of surgical patients, mostly those with hiatal hernia and achalasia cardia, according to PRECISE-diagnostics was defined as reduced, in the form of impaired adaptation in decompensatory type of the relationship between aggressive and protective factors of gastric juice.

Downloads

Download data is not yet available.

References

Kim HG, Cheon EJ, Bai DS, Lee YH, Koo BH. Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature. Psychiatry Investig. 2018 Mar;15(3):235-245. doi:10.30773/pi.2017.08.17.

Aganov S; Pure Purr LLC; Pharmaxi LLC. Randomized, prospective, sham-controlled, blinded, cross-over clinical study of the effect of the virtual reality (VR) technology on the recovery of the indicators of the autonomic nervous system in healthy volunteers affected by moderate stress: clinical trial protocol NCT03532152. Wilmington, Delaware; 2019. 40 р.

Mondéjar-Guerra V, Rouco J, Novo J, Penedo M, Ortega M. Heartbeat classification fusing temporal and morphological information of ECGs via ensemble of classifiers. Biomedical Signal Processing and Control. 2019;47:41-48. doi:10.1016/j.bspc.2018.08.007.

Sen J, McGill D. Fractal analysis of heart rate variability as a predictor of mortality: A systematic review and meta-analysis. Chaos. 2018 Jul;28(7):072101. doi:10.1063/1.5038818.

Sessa F, Anna V, Messina G, et al. Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY). 2018 Feb 23;10(2):166-177. doi:10.18632/aging.101386.

Eremina EYu, Zvereva SI, Kozlova LS. Parameters of heart rate variability in patients with gastroesophageal reflux disease. Experimental and Clinical Gastroenterology. 2018;(9):10-17. doi:10.31146/1682-8658-ecg-157-9-10-17. (in Russian).

Chizhikov DА, Fomin LB, Borisov VI. The use of heart rate variability technique for differential diagnostics of peptic ulcer and idiopathic duodenal ulcers. Sovremennye tehnologii v medicine. 2015;7(2):99-104. doi:10.17691/stm2015.7.2.13. (in Russian).

Nadaleto BF, Herbella FA, Patti MG. Gastroesophageal reflux disease in the obese: Pathophysiology and treatment. Surgery. 2016 Feb;159(2):475-486. doi:10.1016/j.surg.2015.04.034.

Yandrapu H, Sarosiek J. Protective factors of the gastric and duodenal mucosa: an overview. Curr Gastroenterol Rep. 2015 Jun;17(6):24. doi:10.1007/s11894-015-0452-2.

PRECISE automated ECG interpretation. Calofornia, United States; 2018.

Sheleketina II, Kozhukhar' NP, Min'ko AF, Rudenko AI. Kolichestvennyi metod opredeleniia gastromukoproteidov: informatsionnoe pis'mo [Quantitative method for the determination of gastromucoproteins: information letter]. Kyiv; 1983. 3 p. (in Russian).

Rudenko AI, Majkova TV, Mosijchuk LM, et al. Kliniko-laboratorna ocinka funkcional'nogo stanu sekretornyh zaloz shlunka: metodychni rekomendacii' [Clinical and laboratory assessment of the functional state of the secretory glands of the stomach: guidelines]. Kyiv; 2004. 23 p. (in Ukrainian).

Sheleketina II, Kozhukhar' NP, Min'ko AF, Rudenko AI. To the method for determining the activity of pepsin in gastric juice. Laboratornoe delo. 1981;(4):254-255. (in Russian).

Mamaev AN. Osnovy meditsinskoi statistiki [Fundamentals of medical statistics]. Moscow: Prakticheskaia Meditsina; 2011. 128 p. (in Russian).

Published

2022-10-30

How to Cite

Shevchenko, B., Prolom, N., Zyhalo, E., Rudenko, A., Demeshkina, L., & Kyslova, R. (2022). Peculiarities of the relationship between aggressive and protective factors of the gastric mucosa in patients with esophagogastroduodenal pathology with impaired adaptive potential and autonomic homeostasis (according to PRECISE-diagnostics). GASTROENTEROLOGY, 55(4), 223–228. https://doi.org/10.22141/2308-2097.55.4.2021.247912

Issue

Section

Original Researches

Most read articles by the same author(s)

1 2 3 4 5 > >>