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Yu.M. Stepanov; T.S. Tarasova; M.V. Stoykevich

doi:10.22141/2308-2097.55.1.2021.229437

Authors

Yu.M. Stepanov SI “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine https://orcid.org/0000-0002-6721-2468
T.S. Tarasova SI “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine https://orcid.org/0000-0001-6444-6253
M.V. Stoykevich SI “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine https://orcid.org/0000-0002-6111-7267

DOI:

https://doi.org/10.22141/2308-2097.55.1.2021.229437

Keywords:

inflammatory bowel disease, ulcerative colitis, Crohn’s disease, IgG, IgG4, IgG4-related disease

Abstract

Inflammatory bowel disease (IBD), namely ulcerative colitis and Crohn’s disease, which are non-specific inflammation of the gastrointestinal tract, remain one of the most important problems of modern gastroenterology today. The golden standard for the diagnosis of IBD is an endoscopic and histological examination, but the detection and prospects of non-invasive biomarkers will improve the quality of diagnosis, allow developing new methods for predicting the severity of IBD, which in turn will improve therapy, change the quality life of patients with IBD. The studies of the role of humoral immunity in the pathogenesis of IBD have shown that IgG4 may be one of these markers. The article presents a review of modern literature sources on the value of IgG4 in the pathogenesis of IBD, the feasibility and specificity of the determination of IgG4 in blood plasma and tissue IgG4 as a criterion for differential diagnosis of IBD and the possibility of using it as a biomarker for predicting IBD. The search was performed using the database PubMed, MedLine, EMBASE, Cochrane library, Google scholar, Cyberleninka, eLibrary.

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References

Farahmand F, Ahmadi M, Khodadad A, et al. IgG4 subclass and gamma-glutamyl transferase in children with ulcerative colitis with primary sclerosing cholangitis and without sclerosing cholangitis. Clin Exp Hepatol. 2019 Nov;5(4):285-288. doi:10.5114/ceh.2019.89119.

Armstrong H, Alipour M, Valcheva R, et al. Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases. Microbiome. 2019 Jan 3;7(1):1. doi:10.1186/s40168-018-0604-3.

Sub Lee H, Jae Lee K. Immunoglobulin G4-related immune responses to common food antigens in patients with ulcerative colitis and Crohn's disease. Turk J Gastroenterol. 2019 May;30(5):408- 414. doi:10.5152/tjg.2019.18466.

Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015 Dec;12(12):720-727. doi:10.1038/nrgastro.2015.150.

Dmochowska N, Wardill HR, Hughes PA. Advances in Imaging Specific Mediators of Inflammatory Bowel Disease. Int J Mol Sci. 2018 Aug 21;19(9):2471. doi:10.3390/ijms19092471.

Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017 Dec 23;390(10114):2769-2778. doi:10.1016/S0140-6736(17)32448-0.

Kaplan GG, Ng SC. Understanding and Preventing the Global Increase of Inflammatory Bowel Disease. Gastroenterology. 2017;152(2):313-321.e2. doi:10.1053/j.gastro.2016.10.020.

Lamb CA, Kennedy NA, Raine T, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019 Dec;68(Suppl 3):s1-s106. doi:10.1136/gutjnl-2019-318484.

Wang Z, Zhu M, Luo C, et al. High level of IgG4 as a biomarker for a new subset of inflammatory bowel disease. Sci Rep. 2018 Jul 3;8(1):10018. doi:10.1038/s41598-018-28397-8.

Limketkai BN, Wolf A, Parian AM. Nutritional Interventions in the Patient with Inflammatory Bowel Disease. Gastroenterol Clin North Am. 2018 Mar;47(1):155-177. doi:10.1016/j.gtc.2017.09.007.

Lee SH, Kwon JE, Cho ML. Immunological pathogenesis of inflammatory bowel disease. Intest Res. 2018 Jan;16(1):26-42. doi:10.5217/ir.2018.16.1.26.

Šimurina M, de Haan N, Vučković F, et al. Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases. Gastroenterology. 2018 Apr;154(5):1320-1333.e10. doi:10.1053/j.gastro.2018.01.002.

Raina A, Yadav D, Regueiro M, et al. Mucosal IgG4 cell infiltration in ulcerative colitis is linked to disease activity and primary sclerosing cholangitis. Inflamm Bowel Dis. 2013 May;19(6):1232-1237. doi:10.1097/MIB.0b013e318281344d.

Levine A, Rhodes JM, Lindsay JO, et al. Dietary Guidance From the International Organization for the Study of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020 May;18(6):1381-1392. doi:10.1016/j.cgh.2020.01.046.

Magro F, Langner C, Driessen A, et al. European consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis. 2013 Nov;7(10):827-851. doi:10.1016/j.crohns.2013.06.001.

Smids C, Horjus Talabur Horje CS, et al. The value of serum antibodies in differentiating inflammatory bowel disease, predicting disease activity and disease course in the newly diagnosed patient. Scand J Gastroenterol. 2017 Oct;52(10):1104-1112. doi:10.1080/00365521.2017.1344875.

Crescioli S, Correa I, Karagiannis P, et al. IgG4 Characteristics and Functions in Cancer Immunity. Curr Allergy Asthma Rep. 2016 Jan;16(1):7. doi:10.1007/s11882-015-0580-7.

Kamisawa T, Zen Y, Pillai S, Stone JH. IgG4-related disease. Lancet. 2015 Apr 11;385(9976):1460-1471. doi:10.1016/S0140-6736(14)60720-0.

Chen X, Sun W, Lin R, Huang Z, Chen W. IgG4+ plasma cell infiltration is correlated with the development of inflammatory bowel disease and can be regulated by TLR-4. Int J Clin Exp Pathol. 2018 Sep 1;11(9):4537-4544.

Navaneethan U, Liu X, Bennett AE, Walsh RM, Venkatesh PG, Shen B. IgG4-associated ampullitis and cholangiopathy in Crohn's disease. J Crohns Colitis. 2011 Oct;5(5):451-456. doi:10.1016/j.crohns.2011.03.007.

Koutroumpakis F, Phillips AE, Yadav D, et al. Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype. Inflamm Bowel Dis. 2020 Sep 3:izaa230. doi:10.1093/ibd/izaa230.

Şimşek HD, Basyigit S, Aktas B, et al. Comparing the type and severity of inflammatory bowel disease in relation to IgG4 immunohistochemical staining. Acta Gastroenterol Belg. 2016 Apr-Jun;79(2):216-221.

Ministry of Нealth of Ukraine. Order on September 28, 2012 № 751. On Creation and Implementation of Medical and Technological Documents on the Standardization of Medical Care in the System of the Ministry of Health of Ukraine. Available from: https://zakon.rada.gov.ua/laws/show/z2001-12#Text. Accessed: September 28, 2012. (in Ukrainian).

Valenzuela NM, Schaub S. The Biology of IgG Subclasses and Their Clinical Relevance to Transplantation. Transplantation. 2018 Jan;102(1S Suppl 1):S7-S13. doi:10.1097/TP.0000000000001816.

Aryal S. Immunoglobulin G (IgG)- Structure, Subclasses and Functions. Available from: https://microbenotes.com/immunoglobulin-g-igg-structure-subclasses-and-functions/. Accessed: June 24, 2018.

Trampert DC, Hubers LM, van de Graaf SFJ, Beuers U. On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease. Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1401-1409. doi:10.1016/j.bbadis.2017.07.038.

Harkness T, Fu X, Zhang Y, et al. Immunoglobulin G and immunoglobulin G subclass concentrations differ according to sex and race. Ann Allergy Asthma Immunol. 2020 Aug;125(2):190-195.e2. doi:10.1016/j.anai.2020.03.018.

Topal F, Sarıtaş Yüksel E, Ekinci N, et al. The prevalence of IgG4-positive plasma cell infiltrates in inflammatory bowel disease patients without autoimmune pancreatitis. Turk J Gastroenterol. 2014 Oct;25(5):558-562. doi:10.5152/tjg.2014.5714.

Kotani H, Ohtsuka T, Okada S, Kusama M, Taniguchi T. A case of IgG4-related disease presented with Kimura disease-like skin eruption, rheumatoid arthritis-like abnormality and interstitial pneumonia. Clin Exp Dermatol. 2020 Aug;45(6):733-734. doi:10.1111/ced.14222.

Ishikawa H, Uruga H, Fujii T, Kurosaki A, Morokawa N, Takaya H. IgG4-related disease in the differential diagnosis of lung nodules. Respirol Case Rep. 2020 Mar 10;8(4):e00550. doi:10.1002/rcr2.550.

Tang J, Cai S, Ye C, Dong L. Biomarkers in IgG4-related disease: A systematic review. Semin Arthritis Rheum. 2020 Apr;50(2):354-359. doi:10.1016/j.semarthrit.2019.06.018.

Castro-Dopico T, Clatworthy MR. IgG and Fcγ Receptors in Intestinal Immunity and Inflammation. Front Immunol. 2019 Apr 12;10:805. doi:10.3389/fimmu.2019.00805.

Maehara T, Moriyama M, Nakamura S. Review of a novel disease entity, immunoglobulin G4-related disease. J Korean Assoc Oral Maxillofac Surg. 2020 Feb;46(1):3-11. doi:10.5125/jkaoms.2020.46.1.3.

Miyoshi E, Shinzaki S, Fujii H, Iijima H, Kamada Y, Takehara T. Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease. Proteomics Clin Appl. 2016 Apr;10(4):384-390. doi:10.1002/prca.201500089.

Koyabu M, Uchida K, Miyoshi H, et al. Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases. J Gastroenterol. 2010 Jul;45(7):732-741. doi:10.1007/s00535-010-0199-3.

Watanabe T, Yamashita K, Kudo M. IgG4-Related Disease and Innate Immunity. Curr Top Microbiol Immunol. 2017;401:115-128. doi:10.1007/82_2016_42.

Satou A, Notohara K, Zen Y, et al. Clinicopathological differential diagnosis of IgG4-related disease: A historical overview and a proposal of the criteria for excluding mimickers of IgG4-related disease. Pathol Int. 2020 Jul;70(7):391-402. doi:10.1111/pin.12932.

Raess PW, Habashi A, El Rassi E, Milas M, Sauer DA, Troxell ML. Overlapping Morphologic and Immunohistochemical Features of Hashimoto Thyroiditis and IgG4-Related Thyroid Disease. Endocr Pathol. 2015 May;26(2):170-177. doi:10.1007/s12022-015-9368-5.

Nirula A, Glaser SM, Kalled SL, Taylor FR. What is IgG4? A review of the biology of a unique immunoglobulin subtype. Curr Opin Rheumatol. 2011 Jan;23(1):119-124. doi:10.1097/BOR.0b013e3283412fd4.

Deshpande V, Zen Y, Chan JK, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012 Sep;25(9):1181-1192. doi:10.1038/modpathol.2012.72.

Maehara T, Moriyama M, Nakamura S. Review of a novel disease entity, immunoglobulin G4-related disease. J Korean Assoc Oral Maxillofac Surg. 2020 Feb;46(1):3-11. doi:10.5125/jkaoms.2020.46.1.3.

Bueverov AO, Kucheriavyi AO. IgG4-assotsiirovannaia bolezn': monografiia [IgG4-associated disease: monograph]. Moscow: Forte Print; 2014. 128 p. (in Russian).

Ling J, Wang H, Pan W, et al. Clinical and imaging features of IgG4-related kidney disease. Abdom Radiol (NY). 2020 Jun;45(6):1915-1921. doi:10.1007/s00261-020-02477-8.

Ebbo M, Grados A, Daniel L, et al. IgG4-related systemic disease: emergence of a new systemic disease? Literature review. Rev Med Interne. 2012 Jan;33(1):23-34. doi:10.1016/j.revmed.2011.08.012. (in French).

Raparia K, Molina CP, Quiroga-Garza G, Weilbaecher D, Ayala AG, Ro JY. Inflammatory aortic aneurysm: possible manifestation of IgG4-related sclerosing disease. Int J Clin Exp Pathol. 2013;6(3):469-475.

Zhong W, Kam J, Beattie K, Yuminaga Y, Ferguson R, Ko R. A Rare Case of Ureteral IgG4 Disease Masquerading as Urothelial Carcinoma. Urology. 2018 Aug;118:e1-e2. doi:10.1016/j.urology.2018.05.019.

Chang J, Zhang W. Infrequent organ involvement of IgG4-related diseases: a literature review. Clin Rheumatol. 2018 May;37(5):1153-1159. doi:10.1007/s10067-018-4048-8.

Boban J, Ardalı S, Thurnher MM. Leptomeningeal form of Immunoglobulin G4-related hypertrophic meningitis with perivascular spread: a case report and review of the literature. Neuroradiology. 2018 Jul;60(7):769-773. doi:10.1007/s00234-018-2028-y.

Iida T, Wagatsuma K, Hirayama D, Yokoyama Y, Nakase H. The Etiology of Pancreatic Manifestations in Patients with Inflammatory Bowel Disease. J Clin Med. 2019 Jun 26;8(7):916. doi:10.3390/jcm8070916.

Virk R, Shinagare S, Lauwers GY, Yajnik V, Stone JH, Deshpande V. Tissue IgG4-positive plasma cells in inflammatory bowel disease: a study of 88 treatment-naive biopsies of inflammatory bowel disease. Mod Pathol. 2014 Mar;27(3):454-459. doi:10.1038/modpathol.2013.121.

Kuwata G, Kamisawa T, Koizumi K, et al. Ulcerative colitis and immunoglobulin G4. Gut Liver. 2014 Jan;8(1):29-34. doi:10.5009/gnl.2014.8.1.29.

Faria RJ, Clemente CM, Carneiro FP, Santos-Neto L. Can IgG4 Levels Identify the Ulcerative Colitis Subtype of Inflammatory Bowel Disease? Gastroenterology Res. 2015 Apr;8(2):178-185. doi:10.14740/gr648w.