The effectiveness of Colonzak in patients with various clinical variants of irritable bowel syndrome

Abstract

Background. The etiological causes of irritable bowel syndrome (IBS) symptoms have not been fully established. The lack of a clear understanding of the pathogenetic mechanisms of the development of one or another functional intestinal disease, including IBS, taking into account the presence of various structural and morphological disorders in the intestinal wall, dictates the need to search for new drugs, the action of which will be directed to different links in the pathogenesis of intestinal diseases. The aim of the study is to examine the efficacy and safety of Colonzak using in patients with various clinical variants of irritable bowel syndrome. Materials and methods. We examined 42 patients with a verified diagnosis of IBS (14 — IBS type 1; 14 — IBS type 2; 9 — IBS type 3; 5 — IBS type 4) aged 25 to 45 years (average age 35 ± 1.7 years). In all IBS patients, organic intestinal pathology was excluded during colonoscopy. IBS was diagnosed according to Rome IV criteria. In addition to lifestyle modification and adherence to dietary rules, depending on the type of IBS, all patients (regardless of the IBS variant) received monotherapy with Colonzak in a dosage of 1 capsule 2 times a day in the morning and in the evening before meals for 30 days. All patients completed the IBS Symptoms Severity Score (IBS-SSS) questionnaire before and after the study. The results were statistically processed using Excel 2017 (Microsoft) and Statistica 13. Results. The study showed that Colonzak containing probiotic strains of bifidobacteria, prebiotic inulin, and butyric acid can be considered as a safe, well-tolerated, and highly effective drug for the treatment of patients with different types of IBS. In patients with IBS, the use of Colonzak was accompanied by a statistically significant increase in the clinical effectiveness of treatment. Conclusions. Our study has confirmed the clinical efficacy of Colonzak as a multicomponent protector for a colon in IBS. The results obtained allow us to recommend the widespread use of Сolonzak in the complex treatment of patients with different types of IBS.