Efficiency of bioregulatory approach to the comprehensive correction of endogenous intoxication in chronic lesions of the pancreatohepatobiliary system

Abstract

Background. The search for methods of correcting endogenous intoxication is relevant, despite the large number of exis­ting methods for the treatment of diseases of the pancreatohepatobiliary system. The purpose of the research is to study the nature of changes in endogenous intoxication syndrome in patients with chronic pancreatohepatobiliary system lesions during bioregulation therapy (BRT). Materials and methods. Seventy-two patients with chronic pancreatitis in the phase of unstable remission aged 18–62 years were examined, including 15 men and 57 women. Depending on the presence of concomitant pancreatohepatobi­liary pathology, the patients were divided into three groups: chronic viral hepatitis C was first diagnosed in 26 patients (group I), chronic acalculous cholecystitis — in 25 (group II), biliary dyskinesia — in 21 people (group III). All patients were prescribed a course of basic therapy and at the same time a combination bioregulatory corrector of exocrine pancreatic insufficiency and a combination bioregulatory hepatotropic drug. Dynamic changes (before and after during BRT) of middle-molecular weight peptides, circulating immune complexes and leukocyte intoxication index were studied to evaluate endotoxicosis. Results. After the course of BRT, along with the elimination or reduction of pain syndrome, dyspepsia, normalization of bowel activity and other clinical signs of improvement, there was a significant decrease in the level of endogenous intoxication (p < 0.05). According to the middle-molecular weight peptides, circulating immune complexes, and leukocyte intoxication index data, only 33.6 % of patients showed mild signs of endotoxicosis after comprehensive treatment with inclusion of BRT course. Conclusions. The above changes in endogenous intoxication parameters can be regarded as physiological adaptation processes that take place in the human body under the influence of bioregulatory treatment and contribute to the formation of detoxification and sanogenic effects of BRT.