Применение показателей вариабельности сердечного ритма для оценки адаптационных процессов и уровня стресса у гастроэнтерологических больных (использование современных технологий PRECISE-диагностики)

Yu.M. Stepanov; E.V. Zyhalo

doi:10.22141/2308-2097.54.2.2020.206230

Authors

Yu.M. Stepanov State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences”, Dnipro, Ukraine
E.V. Zyhalo State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences”, Dnipro, Ukraine

DOI:

https://doi.org/10.22141/2308-2097.54.2.2020.206230

Keywords:

heart rate variability, vegetative nervous system, gastrointestinal pathology, adaptation, stress, review

Abstract

A vast amount of works is devoted to studying the heart rate variability (HRV). The article covers a literature review on modern concepts about heart rate variability as a method for estimation of mechanisms of physiological functions regulation in a human body, standard methods of the analysis and opportunities of clinical application. The heart rhythm is the indicator of the deviations arising in vegetative nervous system, and change of heart rhythm — the earliest prognostic sign of many diseases. In clinical practice, the analysis of HRV finds wider application in basic diseases in gastroenterological practice (gastroesophageal reflux disease, peptic ulcer, irritable bowel syndrome), interaction of compartments of the vegetative nervous system in various gastroenterological pathologies. Patients with different pathologies of digestive system are examined using the up-to-date Precise-diagnostics to determine adaptive and vegetative disorders in State Institution “Institute of Gastroenterology of Medical Sciences of Ukraine”. Precise-diagnostics defines stress level and possible risk to predict complications in patients with gastrointestinal diseases. The treatment using the virtual reality is used for patients with revealed disorders. The Precise-diagnostics uses a unique cloud-based algorithm to quickly analyze an ECG interpretation and produces within seconds a detailed report based on HRV аnalysis and the full range of the standardized Minnesota Code classification system for electrocardiographic findings. Cloud and the PRECISE Report are the latest medical innovations developed and being brought to market by Precise Cardiology Limited. They are unique detailed cloud-based electrocardiogram instant interpretation products aimed initially at the GP and medical diagnostic companies but with wider potential beyond including artificial intelligence enhancement.

Downloads

Download data is not yet available.

References

Timoshсhuk OV. Diagnosis of impaired adaptation and resistance to stress in children with chronic gastroduodenitis. Zdorov'e rebenka. 2016;(74):108-112. doi:10.22141/2224-0551.6.74.2016.82142. (in Ukrainian).

Marushko JuV, Gyshhak TV. Heart rate variability indicators in the assessment of adaptation processes. Zdorov’ja Ukrai'ny. Pediatrija. 2015;(33):45-46. (in Ukrainian).

Kim HG, Cheon EJ, Bai DS, Lee YH, Koo BH. Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature. Psychiatry Investig. 2018;15(3):235‐245. doi:10.30773/pi.2017.08.17.

Koo KM, Kim CJ. The effect of the type of physical activity on the perceived stress level in people with activity limitations. J Exerc Rehabil. 2018;14(3):361‐366. doi:10.12965/jer.1836164.082.

Stults-Kolehmainen MA, Sinha R. The effects of stress on physical activity and exercise. Sports Med. 2014;44(1):81‐121. doi:10.1007/s40279-013-0090-5.

Shaposhnikova NF, Davydova AN. Possible role of adaptation mechanisms of the autonomic nervous system in gastrointestinal and urinary tract disorders in children. Journal of VolgSMU. 2016;(58):119-121. (in Russian).

Chizhikov DA, Kopytova TV, Borisov V. Gastric ulcer and duodenal ulcer: focus on idiopathic ulcers and vegetative regulation. Medical Almanac. 2016;(41):34-38. (in Russian).

Kseneva SI, Borodulina EV, Udut VV. Discoordination of autonomic function in the pathogenesis of gastroesophageal reflux disease. Bulletin of Experimental Biology and Medicine. 2018;166(7):22-25. (in Russian).

Lebedeva MA, Karganov MYu, Kozlova YuA, et al. The role of autonomic dysfunction in pathogenesis of irritable bowel syndrome. Patologicheskaya Fiziologiya i Eksperimental'naya Terapiya. 2014;58(3):37-44. doi:10.25557/0031-2991.2014.03.37-44. (in Russian).

Kulchytska OM, Stanislavchuk MA. Vegetative imbalance in patients with irritable bowel syndrome. Modern Gastroenterology. 2013;(74):43-45. (in Ukrainian).

Velichko ОN, Datsok OM. Analysis of the heart rate variability dynamics during long-term monitoring. Radiotehnika. 2017;188:79-85. doi:10.1615/telecomradeng.v77.i7.70. (in Ukrainian).

Flyunt ІS, Tymochko OB, Hryvnak RF, Olіyarnyk OYa, Romans'kyi RYu, Tkachuk SP. Relationships of index activity of regulatory systems from Bayevsky with parameters of heart rhytm variability. Medical hydrology and rehabilitation. 2011;9(2):1-7. (in Ukrainian).

Vein AM, Solov'eva AD, Danilov AB, et al., authors; Vein AM, editor. Vegetativnye rasstroistva: klinika, diagnostika, lechenie [Vegetative disorders: clinic, diagnosis, treatment]. Moscow: MIA; 2005. 413-430 pp. (in Russian).

Iabluchanskii NI, Martynenko AV. Variabel'nost' serdechnogo ritma: v pomoshch' prakticheskomu vrachu [Heart rate variability: to help a practitioner]. Kharkiv; 2010. 131 p. (in Russian).

Kovalenko TV, Goryacheva AA, Barsukov AV. Vegetative imbalance features in the patients with peptic ulcer disease: current issues of pathogenesis and treatment. The Scientific Notes of the Pavlov University. 2013;20(2):49-53. (in Russian).

Nalyotov AV. Vegetative dysfunction and way of its correction in children with chronic gastroduodenal pathology. Zdorov'e rebenka. 2014;(54):56-60. doi:10.22141/2224-0551.3.54.2014.76000. (in Ukrainian).

Nikolaev YuA, Sevostyanova EV, Polyakov VYa, et al. State of the autonomic nervous system in patients with dorsopathies, combined with diseases of the upper gastrointestinal tract. Modern problems of science and education. 2016;(2):119. (in Russian).

Panov AA, Antonyan VA, Antonyan SV. Physiotherapy methods of correction of autonomic disorders in duodenal ulcer. Astrakhan Medical Journal. 2017;12(1):90-96. (in Russian).

Araújo MB, Borini P, Guimarães RC. Etiopathogenesis of peptic ulcer: back to the past?. Arq Gastroenterol. 2014;51(2):155‐161. doi:10.1590/s0004-28032014000200016.

Reutov VP, Chertok VM. The new understanding of the autonomic nervous system role and the nitric oxide generating system in the brain vessels. Tihookeanskij medicinskij žurnal. 2016;(64):10-19. (in Russian).

Loranskaya ID, Kozlova YuA. Autonomic disorders in the patophysiology of irritable bowel syndrome. Eksperimental'naia i klinicheskaia gastroenterologiia. 2014;(107):86-90. (in Russian).

Mazurak N, Seredyuk N, Sauer H, Teufel M, Enck P. Heart rate variability in the irritable bowel syndrome: a review of the literature. Neurogastroenterol Motil. 2012;24(3):206-216. doi:10.1111/j.1365-2982.2011.01866.x.

Osyodlo GV, Radushinska MV. The role of vegenanive dysfunction and its correction in gastroesophageal reflux disease. Gastroenterologìa. 2014;(52):13-16. doi:10.22141/2308-2097.2.52.2014.81943. (in Ukrainian).

Dats-Opoka MІ, Hnateyko OZ, Makukh GV. Features of the autonomic (autonomous) nervous system in children with gastroesophageal reflux disease and various genotypes of the C825T locus of the GNB3 gene. Science Rise: Medical Science. 2017;16(8):10-15. doi:10.15587/2519-4798.2017.109148. (in Ukrainian).

Viktorova IA, Grishechkina IA, Sobol' LN. The role of the autonomic nervous system in the pathogenesis of gastroesophageal reflux disease. Young scientist. 2014;(5):128-131. (in Russian).

Nadaleto BF, Herbella FA, Patti MG. Gastroesophageal reflux disease in the obese: Pathophysiology and treatment. Surgery. 2016;159(2):475‐486. doi:10.1016/j.surg.2015.04.034.

Al'tman NS. The role of vegetative disorders in the development of erosive and ulcerative lesions. Fizioterapiya, Bal’neologiya i Reabilitatsiya. 2015;14(2):23-28. (in Russian).

Shelekhova YuV, Hramtsova NA, Onuchina EV, Kuklin SG. Study of the variability of the cardiac rhythm in railroad employees, who suffer by stomach ulcer and duodenum, associated and nonassociated with the infection Helicobacter Pylori. Eksperimental'naia i klinicheskaia gastroenterologiia. 2015;(118):36-40. (in Russian).

Tomina EE, Yabluchanskiy NI. Peptic ulcer disease: change of notions and approaches, accents to the heart rate variability. Journal of VN Karazin Kharkiv National University. Medicine. 2008;(7970:129-140. (in Russian).

Nomura M, Yukinaka M, Miyajima H, et al. Is autonomic dysfunction a necessary condition for chronic peptic ulcer formation?. Aliment Pharmacol Ther. 2000;14 (Suppl 1):82-86. doi:10.1046/j.1365-2036.2000.014s1082.x.

Zaytseva MR, Makhonko MN, Shelekhova TV, Aleshechkina EE, Luchinina EV. Features of psychovegetative status of patients with different clinical course of irritable bowel syndrome. Modern problems of science and education. 2015;(5):304. (in Russian).

Pellissier S, Dantzer C, Canini F, Mathieu N, Bonaz B. Psychological adjustment and autonomic disturbances in inflammatory bowel diseases and irritable bowel syndrome. Psychoneuroendocrinology. 2010;35(5):653-662. doi:10.1016/j.psyneuen.2009.10.004.

Emmanuel A. Neurogenic bowel dysfunction. F1000Res. 2019;8:F1000 Faculty Rev-1800. doi:10.12688/f1000research.20529.1.

Sen J, McGill D. Fractal analysis of heart rate variability as a predictor of mortality: A systematic review and meta-analysis. Chaos. 2018;28(7):072101. doi:10.1063/1.5038818.

Sessa F, Anna V, Messina G, et al. Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY). 2018;10(2):166-177. doi:10.18632/aging.101386.

Borovkova EI, Skazkina VV, Kiselev AR, et al. Ultra-low frequency dynamics of subsystems of autonomic control of heart rate and vascular tone in healthy subjects. Annals of Arrhythmology. 2017;14(2):114-120. doi:10.15275/annaritmol.2017.2.7. (in Russian).

Mondéjar-Guerra V, Rouco J, Novo J, Penedo M, Ortega M. Heartbeat classification fusing temporal and morphological information of ECGs via ensemble of classifiers. Biomedical Signal Processing and Control. 2019;47:41-48. doi:10.1016/j.bspc.2018.08.007.

Ivanov AP, Kudinov AN, Lebedev DYu, Miheev SA, Cvetkov VP, Cvetkov IV. Catastrophes instantaneous heart rate in the model multifractal dynamics and based on the data of Holter monitoring. Matematicheskoe modelirovanie. 2017;29(5):73-84. doi:10.1016/j.chaos. (in Russian).

Billman GE, Sacha J, Werner B, Jelen PJ, Gąsior JS. Editorial: Heart Rate Variability and Other Autonomic Markers in Children and Adolescents. Front Physiol. 2019;10:1265. doi:10.3389/fphys.2019.01265.

Shaffer F, Ginsberg JP. An Overview of Heart Rate Variability Metrics and Norms. Front Public Health. 2017;5:258. doi:10.3389/fpubh.2017.00258.

Thayer JF, Ahs F, Fredrikson M, Sollers JJ 3rd, Wager TD. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev. 2012;36(2):747-756. doi:10.1016/j.neubiorev.2011.11.009.

Prineas RJ, Crow RS, Zhang ZM. The Minnesota Code Manual of Electrocardiographic Findings. London, UK: Springer-Verlag Ltd; 2010. 328 p. doi:10.1007/978-1-84882-778-3.

PRECISE - automated ECG interpretation. Calofornia, US; 2018.

PRECISE Cloud ECG Interpretation: Breakthrough Invention That One Day Might Save Your Life. Available from: https://www.prweb.com/releases/2017/12/prweb15027249.htm. Accessed: December 19, 2017.

Aganov S; Pure Purr LLC; Pharmaxi LLC. Randomized, prospective, sham-controlled, blinded, cross-over clinical study of the effect of the virtual reality (VR) technology on the recovery of the indicators of the autonomic nervous system in healthy volunteers affected by moderate stress: clinical trial protocol PurePurr-001, version 2.6. Kyiv, Ukraine; 2018. 40 p.

Aganov S, Vasylenko Y, Lebid YuV. Clinical Study of the Effect of the Virtual Reality (VR) Technology on Recovery of the Indicators of the Autonomic Nervous System in Healthy Volunteers Affected by Moderate Stress: clinical trials study NCT03532152. Available from: https://www.clinicaltrials.gov/ct2/show/record/NCT03532152. Accessed: April 16, 2019.

Jirakittayakorn N, Wongsawat Y. The brain responses to different frequencies of binaural beat sounds on QEEG at cortical level. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:4687-4691. doi:10.1109/EMBC.2015.7319440.

McConnell PA, Froeliger B, Garland EL, Ives JC, Sforzo GA. Auditory driving of the autonomic nervous system: Listening to theta-frequency binaural beats post-exercise increases parasympathetic activation and sympathetic withdrawal. Front Psychol. 2014;5:1248. doi:10.3389/fpsyg.2014.01248.

Barratt EL, Davis NJ. Autonomous Sensory Meridian Response (ASMR): a flow-like mental state. PeerJ. 2015;3:e851. doi:10.7717/peerj.851.