Особенности фармакотерапии гастроэзофагеальной рефлюксной болезни у беременных

Yu.S. Breslavets

doi:10.22141/2308-2097.53.3.2019.181472

Authors

Yu.S. Breslavets State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine

DOI:

https://doi.org/10.22141/2308-2097.53.3.2019.181472

Keywords:

gastroesophageal reflux disease, pregnancy, pathogenesis, treatment, review

Abstract

The article deals with the problem of gastroesophageal reflux disease in pregnant women. The peculiarities of the mechanism of developing this disease in pregnant women are highlighted. A number of scientific studies of different authors on the safety of therapeutic measures in this category of patients have been analyzed. The author focuses on the presence of unresolved issues in pharmacotherapy for gastroesophageal reflux disease in pregnant women.

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References

WGO. WGO Practice Guideline - Gastroesophageal Reflux Disease (GERD) 2015. Available from: http://www.worldgastroenterology.org/guidelines/global-guidelines/gastroesophageal-reflux-disease.

El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014 Jun;63(6):871–80. doi: 10.1136/gutjnl-2012-304269.

Habr F, Raker C, Lin CL, Zouein E, Bourjeily G. Predictors of gastroesophageal reflux symptoms in pregnant women screened for sleep disordered breathing: a secondary analysis. Clin Res Hepatol Gastroenterol. 2013 Feb;37(1):93-9. doi: 10.1016/j.clinre.2012.03.036.

Herregods TV, Bredenoord AJ, Smout AJ. Pathophysiology of gastroesophageal reflux disease: new understanding in a new era. Neurogastroenterol Motil. 2015 Sep;27(9):1202-13. doi: 10.1111/nmo.12611.

Ramya RS, Jayanthi N, Alexander PC, Vijaya S, et al. Gastroesophageal reflux disease in pregnancy: a longitudinal study. Trop Gastroenterol. 2014 Jul-Sep;35(3):168-72.

Heidelbaugh JJ. Gastroesophageal Reflux Disease (GERD). Ambulatory Clinical Guidelines Oversight. 2018. Available from: https://www.med.umich.edu/1info/FHP/practiceguides/gerd/gerd.12.pdf.

Zaydieva ZS, Prozorov VV. Gastroesophageal reflux disease in pregnant women: pathogenesis, clinic, prevention, treatment. RMJ. 2010;18(19):1199-203.

Rayner C. Dealing with gastro–oesophageal reflux disease during pregnancy. Med Today. 2005;6:65-66.

Turan I, Kitapcioglu G, Tavmergen Goker E, et al. In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease. United European Gastroenterol J. 2016 Apr;4(2):221-8. doi: 10.1177/2050640615597836.

Goral V. Ideal Approach to Gastroesophageal Reflux in Pregnancy. M J Gast. 2018; 3(1):011.

Scherbinina MB, Lugovskaja TV, Ivanchenko N. Heartburn of pregnant women: reasons and opportunities to improve the quality of life of women during this period. Health of woman. 2016;(108):80-86.

Malferttheiner SF, Malfertheiner MV, Kropf S, Costa SD, Malfertheiner P. A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy. BMC Gastroenterol. 2012 Sep 24;12:131. doi: 10.1186/1471-230X-12-131.

Wu JC. Gastroesophageal reflux disease: an Asian perspective. J Gastroenterol Hepatol. 2008 Dec;23(12):1785-93. doi: 10.1111/j.1440-1746.2008.05684.x.

Shehtman MN, Korot'ko GF, Burkov SG. Physiology and pathology of digestive organs in pregnant women. Tashkent: Medicine; 1989. 158 p.

MacFarlane B. Management of gastroesophageal reflux disease in adults: a pharmacist’s perspective. Integr Pharm Res Pract. 2018 Jun 5;7:41-52. doi: 10.2147/IPRP.S142932.

Grishenko VI, Sherbina NA, Lipko OP, et al. Techenie beremennosti i rodov pri ekstragenital'nykh zabolevaniiakh [Course of pregnancy and childbirth in case of extragenital diseases]. Kharkov; 1992. 191 p.

Fajer AB, Holzbauer M, Newport HM. The contribution of the adrenal gland to the total amount of progesterone produced in the female rat. J Physiol. 1971 Apr;214(1):115-26. doi: 10.1113/jphysiol.1971.sp009422.

Adam MP, Polifka JE, Friedman JM. Evolving knowledge of the teratogenicity of medications in human pregnancy. Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):175-82. doi: 10.1002/ajmg.c.30313.

Dolk H, Loane M, Teljeur C, et al. Detection and investigation of temporal clusters of congenital anomaly in Europe: seven years of experience of the EUROCAT surveillance system. Eur J Epidemiol. 2015 Nov;30(11):1153-64. doi: 10.1007/s10654-015-0012-y.

Nordeng H, Ystrøm E, Einarson A. Perception of risk regarding the use of medications and other exposures during pregnancy. Eur J Clin Pharmacol. 2010 Feb;66(2):207-14. doi: 10.1007/s00228-009-0744-2.

Justina VD, Gonçalves JS, David FL, Giachini FR, Lima VV. Evaluation of drug prescriptions for pregnant women in the Legal Amazon Region. Rev Bras Saude Mater Infant. 2018;18(4). doi: 10.1590/1806-93042018000400004.

FDA News Release. FDA issues final rule on changes to pregnancy and lactation labeling information for prescription drug and biological products. Available from: https://www.fda.gov/drugs/labeling/pregnancy-and-lactation-labeling-drugs-final-rule. Accessed August 1, 2019.

FDA Consumer Articles. Pregnant? Breastfeeding? Better Drug Information Is Coming. Available from: https://www.fda.gov/consumers/consumer-updates/pregnant-breastfeeding-better-drug-information-coming. Accessed August 1, 2019.

Mospan C. New Prescription Labeling Requirements for the Use of Medications in Pregnancy and Lactation. CE for Pharmacists. The Ohio Pharmacist Foundation. Accessed August 1, 2019. [Internet]. Available from: https://cdn.ymaws.com/www.wsparx.org/resource/resmgr/CE_Magazine/WA_0416_State_CE_Lesson.pdf

Shi S, Klotz U. Proton pump inhibitors: an update of their clinical use and pharmacokinetics. Eur J Clin Pharmacol. 2008 Oct;64(10):935-51. doi: 10.1007/s00228-008-0538-y.

Australian government: Therapeutic Goods Administration. Prescribing medicines in pregnancy database. 2019. Available from: https://www.tga.gov.au/prescribing-medicines-pregnancy-database.

Categories of drugs for pregnancy. 2019. Available from: https://uk.wikipedia.org/wiki/.

Quartarone G. Gastroesophageal reflux in pregnancy: a systematic review on the benefit of raft forming agents. Minerva Ginecol. 2013 Oct;65(5):541-9.

Tygat GN, McColl K, Tack J, et al. New algorithm for the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2008 Feb 1;27(3):249-56.

Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005 Nov 1;22(9):749-57. doi:10.1111/j.1365-2036.2005.02654.x.

Ruigomez A, Garcia Rodriguez LA, Cattaruzzi C, et al. Use of cimetidine, omeprazole, and ranitidine in pregnant women and pregnancy outcomes. Am J Epidemiol. 1999 Sep 1;150(5):476-81. doi:10.1093/oxfordjournals.aje.a010036.

Berkovitch M, Elbirt D, Addis A, Schuler-Faccini L, Ornoy A. Fetal effects of metoclopramide therapy for nausea and vomiting of pregnancy. N Engl J Med. 2000 Aug 10;343(6):445-6. doi:10.1056/NEJM200008103430616.

Briggs GG, Freeman RY, Yaffe SJ. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Obstet Med. 2009 Jun; 2(2): 89. doi: 10.1258/om.2009.090002.

Matok I, Gorodischer R, Koren G, Sheiner E, Wiznitzer A, Levy A. The safety of metoclopramide use in the first trimester of pregnancy. N Engl J Med. 2009 Jun 11;360(24):2528-35. doi: 10.1056/NEJMoa0807154.

Sachs G, Shin JM, Howden CW. The clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther. 2006 Jun;23 Suppl 2:2-8. doi: 10.1111 / j.1365-2036.2006.02943.x.

Dağlı Ü, Kalkan İH. Treatment of reflux disease during pregnancy and lactation. Turk J Gastroenterol. 2017 Dec;28(Suppl 1):S53-S56. doi: 10.5152/tjg.2017.14.

Pasternak B., Hviid A. Use of proton-pump inhibitors in early pregnancy and the risk of birth defects. N Engl J Med. 2010 Nov 25;363(22):2114-23. doi: 10.1056/NEJMoa1002689.

Gerson L.B. Proton pump inhibitors and pregnancy safety. Gastroenterology. 2011 Jul;141(1):389-91. doi: 10.1053/j.gastro.2011.05.017.