Clinical and endoscopic parallels in ulcerative colitis

Abstract

Background. Currently, there is no ideal way to assess the activity of ulcerative colitis (UC), which determines the re­levance of studying the characteristics of the course of this patho­logy with a comparative analysis of typical clinical and endoscopic manifestations. The purpose is to optimize the diagnosis of UC. Materials and methods. Sixty patients with a confirmed diagnosis of UC were examined, 31 (51.7 %) men and 29 (48.3 %) women aged 21 to 63 years (the average age was (40.28 ± 21.34) years), among them — 52 (86.6 %) persons of working age. Results. The distribution of patients according to the Mayo combined index showed that 36 (60.0 %) individuals had a moderate degree of UC exacerbation, the average indicator was (8.12 ± 0.29) points; in 24 (40.0 %) cases, a severe degree was diagnosed, the average value of the index was (11.38 ± 0.48) points. Correlation analysis of UC activity indices showed a correlation between the degree of disease activity according to the Mayo combined index and clinical activity according to the D. Rachmilewitz scale (r = 0.459; p < 0.01), and the seve­rity of UC flare-up according to S. Truelove and L. Witts criteria (r = 0.526; p < 0.01) and endoscopic activity — to the partial Mayo score (r = 0.598; p < 0.01). Conclusions. The established clinical and endoscopic relationships in UC confirm the need for an integrated approach to the diagnosis of this disease. Given that the degree of spread of inflammation and the severity of UC flare-up affect patient’s management and the evaluation of therapeutic interventions, clinical and endoscopic indicators are useful for standardizing disease activity.