Таурин та його секрети в експериментальній гепатології

I.N. Kononov; V.N. Muslin; D.A. Ptushkina

doi:10.22141/2308-2097.51.3.2017.112633

Authors

I.N. Kononov State Institution “Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine”, Dnipro, Ukraine
V.N. Muslin Dnipropetrovsk District Hospital, Dnipro, Ukraine
D.A. Ptushkina State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, Ukraine

DOI:

https://doi.org/10.22141/2308-2097.51.3.2017.112633

Keywords:

taurine, liver, bile acids, hepatotoxicity, fatty liver disease, cytoprotective propertie

Abstract

Taurine is a unique amino acid. It has various biological effects aimed at maintaining physiological homeostasis, including antioxidation, modulation of ion transport, osmoregulation, regulation of neurotransmitters and conjugation of bile acids. Its regulatory effect on the normalization of protein, carbohydrate, electrolyte metabolism, the activity of a number of enzymes and hormones, the energy and recovery processes in the body, the strengthening of the immune system are associated with the stabilizing effect of taurine on the membranes. Its conjugation with bile acids contributes to the colloidal stability of bile, which is extremely necessary to maintain a normal level of cholesterol in the blood. The treatment and prevention of various diseases of the cardiovascular system, liver, obesity, dyslipidemia and atherosclerosis, as well as insulin resistance and manifested diabetes mellitus, eye diseases, neuroses and depressions are associated with the normalization of the exchange of taurine in the liver. The purpose of this article is to draw attention to taurine as a powerful hepatoprotector, based on experimental studies.

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