Features of Colon Microbiocenosis and Faecal Calprotectin Level in Patients with Chronic Inflammatory Bowel Diseases Depending on the Nutritional Status

Authors

  • N.V. Vinnyk State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk
  • O.M. Tatarchuk State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk
  • M.V. Stoikevych State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk
  • V.Ye. Kudriavtseva State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk
  • O.V. Sorochan State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk

DOI:

https://doi.org/10.22141/2308-2097.2.60.2016.74724

Keywords:

chronic inflammatory bowel diseases, nutritional status, dysbiosis, microflora of the bowel, calprotectin.

Abstract

The article deals with an actual problem — the state of the microflora of the colon and faecal calprotectin level in patients with chronic inflammatory bowel diseases with different nutritional status. The study involved 76 patients with chronic inflammatory bowel diseases, including 28 patients with Crohn’s disease and 48 — with ulcerative colitis. We analyzed the findings depending on the nosology and nutritional status. It was found that among the patients of studied groups, patients with subcompensated form of dysbiosis dominated. Reducing the concentration of bifidobacteria in the colon content of patients from group III was detected more often — in 78.9 % of cases. Deficiency of lactobacilli was most often observed in patients of group II (92.3 %). The content of calprotectin was significantly increased in 84.2 % of patients, it positively correlated with the degree of severity of the disease and did not depend on their nutritional status.

Downloads

Download data is not yet available.

Author Biographies

N.V. Vinnyk, State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk

Laboratory of Microbiology and Immunology

O.M. Tatarchuk, State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk

Laboratory of Microbiology and Immunology

M.V. Stoikevych, State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk

Laboratory of Microbiology and Immunology

V.Ye. Kudriavtseva, State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk

Laboratory of Microbiology and Immunology

O.V. Sorochan, State Institution «Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine», Dnipropetrovsk

Laboratory of Microbiology and Immunology

References

Adler G., Fiocchi C., Lazebnik L.B., Vorobiev G.I. Inflammatory Bowel Disease diagnostic and therapeutic strategies. − Springer, 2007. − 237 p.

Rumyantsev V.G. Ulcerative colitis: a guide for physicians. - Moscow: Medical News Agency, 2009. − 424 р. (In Russ.)

Kanshin O.A., Kanshin N. Ulcerative colitis in children (and rooted). - M.: Bioinformservis, 2002. − 212 р. (In Russ.)

Gastroenterology: national leadership / under. Ed. V.T. Ivashkina, T.L. Lapina. - M.: GEOTAR Media, 2008. − 704 р. (In Russ.)

Abaturov O.E., Stepanova J.J. Determination of fecal kalprotektyn with rotavirus infection in children. Gastroenterology. 2014; (4): 106-109 (In Russ.).

Stepanov J.M., Fedorova N.S. Contents fecal kalprotektyn in patients with chronic inflammatory bowel disease. Current gastroenterology. 2010; (2): 44-48 (In Russ.).

Tatyanyna O.F., Potapov A.S., Namazova L.S., Cimbalova E.G., Kucherenko A.G., Surkov A.N. Markers intestinal inflammation in the bowel disease: review of literature. Pediatric pharmacology. 2008; (3): 39-45 (In Russ.).

Tatyanyna O.F., Potapov A.S., Namazova L.S., Cimbalova E.G., Kucherenko A.G., Lokhmatov M.M. Fecal calprotectin in the non-invasive diagnosis of inflammatory bowel disease in children. Pediatric pharmacology. 2008; (3): 46-51 (In Russ.).

Dolgih T.I. Fecal calprotectin - a non-invasive biomarker of inflammatory bowel process. Special edition laboratory. 2013; (3): 44-46 (In Russ.).

Roset A.G., Aadland E., Grzyb K. Normalization of faecal calprotectin: a predictor of healing in patients with inflammatory bowel. Scand. University Press. 2004; (9): 1012-1017.

Roseth A.G., Aadland E., Jahnsen J. Assessment of disease activity in ulcerative colitis by faecal calprotectin, a novel granulocyte marker protein. Digestion. 1997; (58): 176-180.

Bistrian B. Role of the systemic inflammatory response in the development of protein"energy malnutrition in Inflammatory bowel disease. Inflammatory Bowel Diseases: Nestle Nutrition Workshop Series Clinical & Performance Programme. 1999; (2): 1–6.

Sindeeva L.V., Kazakova G.N. Anthropometry and bioimpedance: parallels and differences. Fundamental research. 2013; (9): 476-480 (In Russ.).

Luft V.M., Tkachenko E.I. Trophological failure and its diagnostic criteries. Military Medical Journal. 1993; (12): 21-24 (In Russ.).

Rocha R., Santana G.O., Almeida N., Lyra A. C. Analysis of fat and muscle mass in patients with inflammatory bowel disease during remission and active phase. Br. J. Nutr. 2009; (101): 676-679.

Wang J., Thornton J.C., Kolesnik S., Pierson R.N. Anthropometry in body composition: An overview Ann. N.Y. Acad. Sci. 2000; ( 904): 317–326.

Downloads

Published

2021-09-07

How to Cite

Vinnyk, N., Tatarchuk, O., Stoikevych, M., Kudriavtseva, V., & Sorochan, O. (2021). Features of Colon Microbiocenosis and Faecal Calprotectin Level in Patients with Chronic Inflammatory Bowel Diseases Depending on the Nutritional Status. GASTROENTEROLOGY, (2.60), 21–25. https://doi.org/10.22141/2308-2097.2.60.2016.74724

Issue

No. 2.60 (2016)

Section

Original Researches

License

Copyright (c) 2016 N.V. Vinnyk, O.M. Tatarchuk, M.V. Stoikevych, V.Ye. Kudriavtseva, O.V. Sorochan

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Most read articles by the same author(s)

1 2 3 > >>