Практические подходы к ведению больных с диспепсией

S.M. Tkach

doi:10.22141/2308-2097.1.59.2016.74534

Authors

S.M. Tkach Ukrainian Scientific and Practical Centre for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Healthcare of Ukraine, Kyiv

DOI:

https://doi.org/10.22141/2308-2097.1.59.2016.74534

Keywords:

dyspepsia, Maastricht consensus, proton pump inhibitors, prokinetics.

Abstract

The article deals with the problem of the treatment of dyspepsia syndrome. Since recently the majority of patients with functional dyspepsia have a combination of symptoms of epigastric pain syndrome and postprandial distress syndrome, in practice combined therapy with proton pump inhibitors (PPIs) and prokinetics is used much more often as first-line empiric treatment. In this respect, administration of ready-to-use fixed combination, such as Omez D or Omez DCR containing IPPs and safe dose of domperidone, is very convenient.

Downloads

Download data is not yet available.

References

A randomized, double-blind, placebo- and positive-controlled, single- and multiple-dose, 4-way crossover study to evaluate the effects of domperidone on cardiac repolarization in healthy subjects. EudraCT number: 2012-001567-70, NCT No: NCT01643889 // Clin. Reg. No.: CR100893

Arleen М. et al. Clinical experience and cardiovascular safety profile of domperidone therapy for nausea and vomiting // Gastroenterology. — 2014. — 146 (5). — S268.

Malfertheiner P., Megraud F., O’Morain C.A. et al. Management of Helicobacter pylori infection: the Maastricht IV/ Florence Consensus Report // Gut. — 2012. — Vol. 61 (5). — 646-664.

Moayyedi P., Deeks J., Talley N.J., Delaney B., Forman D. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews // American Journal of Gastroenterology. — 2003. — 98. — 2621-6.

Moayyedi P., Soo S., Deeks J., Forman D., Harris A., Innes M., Delaney B. Systematic review: Antacids, H2-receptor antagonists, prokinetics, bismuth and sucralfate therapy for non-ulcer dyspepsia // Alimentary Pharmacology and Therapeutics. — 2003. — 17. — 1215-27.

Moayyedi P., Delaney B.C., Vakil N., Forman D., Talley N.J. The efficacy of proton pomp inhibitors in nonulcer dyspepsia. — a systematic review and economic analysis // Gastroenterology. — 2004. — 127. — 1329-37.

Moayyedi P., Soo S., Deeks J., Delaney B., Innes M., Forman D. Pharmacological interventions for non-ulcer dyspepsia // Cochrane Database Sytem. Rev. — 2006. — Oct 18. — CD001960.

Sakurai К. et al. Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS) // BMC Gastroenterol. — 2012 May. — 1. — 12-42.

Sugano K., Tack J., Kuipers E.J. et al. Kyoto global consensus report on management of Helicobacter pylori gastritis // Gut. — 2015. — 64. — 1353-1367

Tack J., Bisschops R., Sarnelli G. Pathophysiology and treatment of functional dyspepsia // Gastroenterology. — 2004. — 127. — 1239-55.

Tack J., Talley N.J., Camilieri M. et al. Functional Gastroduodenal Disorders // Gastroenterology. — 2006. — 130. — 1466-1479

Van Marrewijk C., Mujakovic S., Fransen G.A.J. et al. Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): A primary-care-based randomized controlled trial // Lancet. — 2009. — 373. — 215-225.

van Roeden S.E. et al. Domperidone and the risk of sudden cardiac death // Ned. Tijdschr. Geneeskd. — 2013. — 157 (45). — A6770.