Metabolic therapy in the comprehensive treatment of patients with comorbidity of chronic pancreatitis and stable coronary artery disease
Metabolic therapy is one of the few ways to restore normal functions of all the vital organs and systems. The goal of the research was to explore the effectiveness of a course of treatment using metabolic drug Vazonat (meldonium dihydrate) to correct prooxidant-antioxidant and trophological disorders in patients with comorbid course of chronic pancreatitis (CP) and stable coronary artery disease (SCAD). The study included 90 patients with CP in combination with SCAD, who were divided into two groups (depending on the treatment program): I group (45 patients) received conventional treatment (CT); group II (45 patients) in addition to CT received Vazonat as follows: 5 ml intravenous bolus injection 1 time a day for 10 days followed by administration of 1 capsule (250 mg), 2 times per day for one month. It has been shown that the addition of Vazonat to the treatment of patients with comorbidity of CP and SCAD is more conducive to improving the performance and trophological prooxidant-antioxidant status than the standard basic therapy.
Full Text:PDF (Українська)
Babinets LS. Vitamin and antioxidant imbalance in a clinical picture of chronic pancreatitis in a practice of a family doctor. Sіmejna medicina. 2014;1(51):122-124. (in Ukrainian).
Babinets LS, Migen’ko LM, Migen’ko BO. Rol' dislіpoproteїnemіj u formuvannі porushen' vuglevodnogo obmіnu ta trofologіchnogo statusu pri hronіchnomu pankreatitі [Role of dyslipidemia in development of carbohydrate metabolic impairment and trophological status in chronic pancreatitis]. Proceedings of scientific conference with international participation Diabetes mellitus as an integral problem in internal medicine. 2015 September 11; Kharkiv, Ukraine; 2013. 24-25. (in Ukrainian).
Melnyk NA, Babinets LS. Projavi lіpіdnogo distres-sindromu pri komorbіdnostі hronіchnogo pankreatitu ta іshemіchnoї hvorobi sercja [Signs of lipid distress syndrome in comorbid pancreatitis and ischemic heart disease]. In: Proceeding of scientific conference Diabetes Mellitus as an Integral Problem in Internal Medicine. 2015 September 11; Kharkiv, Ukraine. Kharkiv; 2105. 143p. (in Ukrainian).
Babіnec LS, Mel'nik NA, Cibul's'ka LS, Skripnik MV. Features of anemic syndrome as a sign of trophologic insufficiency against ischemic heart disease. Zdobutky klinichnoi' i eksperymental'noi' medycyny. 2016;2(26):29-32. (in Ukrainian).
Gubergrits NB, Bondarenko OA. Indicators of ultrasonic histography of the pancreas in the dynamics of treatment of patients with chronic pancreatitis on the background of obesity. Hastroenterolohiya. 2013;2:64-67. (in Russian).
Duggan SN, Smyth ND, O'Sullivan M, Feehan S, Ridgway PF, Conlon KC. The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis. Nutr Clin Pract. 2014;29:348-54. doi: 10.1177/0884533614528361. Epub 2014 Apr 11.
Harchenko NV, Anohina GA. Dієtologіja [Dietology]. Kiev: Meridian; 2012. 528p. (in Russian).
Harchenko NV. Vіl'noradikal'ne okisnennja ta stan antioksidantnogo zahistu u hvorih na hronіchnі gepatiti [Free-radical oxidation and antioxidant protection in patients with chronic hepatitis]. In: Gastroenterologіja: mіzhvіdomchij zbіrnik. Issue 32. Dnipropetrovsk; 2013. 504-9. (in Ukrainian).
Arhіj EJ, Myshanich TV, Moskal OM. Characteristics of digestion, laboratory and immunological parameters in patients with pancreas diseases combined with ischemic heart disease and hepatobiliary pathology. Hastroenterolohiya. 2012;46:56-62. (in Ukrainian).
Sikkens EC, Cahen DL, van Eijck C, Kuipers EJ, Bruno MJ. Patients with exocrine insufficiency due to chronic pancreatitis are undertreated: a Dutch national survey. J Pancreatol Official J Int Assoc Pancreatol. 2012;12(1):71-3. doi: 10.1016/j.pan.2011.12.010. Epub 2011 Dec 31.
Tignor AS, Wu BU, Whitlock TL, Lopez R, Repas K, Banks PA, et al. High prevalence of low-trauma fracture in chronic pancreatitis. J Gastroenterol. 2010;105:80-6. doi: 10.1038/ajg.2010.325. Epub 2010 Aug 24.
Schneider A, Löhr JM, Singer MV. The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease. J Gastroenterol. 2007;42:101-19. doi: 10.1007/s00535-006-1945-4.
Copyright (c) 2017 GASTROENTEROLOGY
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2019