Significance of intestinal metaplasia and dysplasia in morphological diagnosis of patients with chronic reflux gastritis
The present study was undertaken to analyze biopsies in 120 cases of chronic reflux gastritis with the help of modern histological, histochemical and morphometric methods. Histological study showed atrophic processes in the gastric mucosa in 73.3 % of cases, while in 46.7 %, atrophy was accompanied by deeper processes: intestinal metaplasia and hyperplasia, and in 15.0 % — by dysplasia of gastric glands. Authors proposed the use of the integral index “intestinal metaplasia + dysplasia” as an additional criterion for assessing the severity of precancerous changes in the mucous membrane of the stomach in patients with chronic reflux gastritis, which was significantly associated with hyperplasia of the gastric glands, infection of H.pylori, increasing levels of nitrites and tendency to increase the level of nitrates and gastrin.
Full Text:PDF (Українська)
Lee JY, Park HW, Choi JY, Lee JS, Koo JE, Chung EJ, et al. Helicobacter pylori infection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm. Gut Liver. 2016 Nov 15;10(6):902-909. doi: 10.5009/gnl15340.
Chiba T, Kato K, Masuda T, Ohara S, Iwama N, Shimada T, Shibuya D. Clinicopathological features of gastric adenocarcinoma of the fundic gland (chief cell predominant type) by retrospective and prospective analyses of endoscopic findings. Dig Endosc. 2016;28(7):722-730. doi: 10.1111/den.12676. Epub 2016 Jun 15.
Fujii I, Watanabe H, Naito M, Kawashima K, and Ito A. The induction of intestinal metaplasia in rats by pyloroplasty or pyloroplasty plus vagotomy. Pathol Res Pract. 1985;180:502-5. doi: 10.1016/S0344-0338(85)80012-1.
Watanabe H, Okamoto T, Fudaba Y, Ogundigie PO, and Ito A. Influence of gastric pH modifiers on development of intestinal metaplasia induced by X-irradiation in rats. Jpn J Cancer Res. 1993;84:1037–42.
Kinoshita K, Watanabe H, Ando Y, Katayama M, Yamamoto H, Hirano N, Yoshikuni S, and Yamamoto T. Effects of subtotal resection of the fundus on development of intestinal metaplasia induced by X-ray irradiation in Donryu rats. Pathol Int. 2000;50:879-83.
Aruin LI, Kapuller LL, Isakov VA. Morfologicheskaja diagnostika boleznej zheludka i kishechnika [Morphological diagnosis of stomach and intestinal diseases]. Мoscow: Triada-Х; 1998. 496p.
Volkov VS, Kolesnikova IYu, Belyaeva GS, Durov VV Schepachev AG, Makarov II, Alexandrov SS. On the role of duodenal reflux in the pathogenesis of duodenal ulcer. Terapevticheskaja gastrojenterologija. 2003;1:12-17.
Korzhevsky DE, Gilyarov AV. Osnovy gistologicheskoj tehniki [Basics of histologic techniques]. St. Petersburg: SpetsLit; 2010.
Samuels ML, Witmer AJ, Schaffner A. Statistics for the Life Sciences. 4th ed. – New York: Pearson; 2012.
Copyright (c) 2017 GASTROENTEROLOGY
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2019