Proton Pump Inhibitors: How Safe is Long Usage of Pantoprazole?

Yu.M. Stepanov, I.Ya. Budzak

Abstract


The article deals with the approaches to treatment of acid-related diseases, there was determined key role of proton pump inhibitors. The special attention was given to safety of long usage of proton pump inhibitors, there were analyzed the findings of investigations regarding their influence on the state of gastroduodenal zone. The findings of research showing the safety of long-term treatment with pantoprazole during 15 years were considered in detail.

Keywords


acid-related diseases; proton pump inhibitors; pantoprazole

References


Brunner G., Athmann C., Schneider A. Long-term, open-label trial: safety and efficacy of continuous maintenance treatment with pantoprazole for up to 15 years in severe acid-peptic disease // Aliment. Pharmacol. Ther. — Jul. 2012. — 36(1). — 37-47.

Fujimoto K., Hongo M. Safety and efficacy of long-term maintenance therapy with oral dose of rabeprazole 10 mg once daily in japanese patients with reflux esophagitis // Intern. Med. — 2011. — 50. — 179-88.

Hirschowitz B.I., Simmons J., Mohnen J. Long-term lansoprazole control of gastric acid and pepsin secretion in ZE and non-ZE hypersecretors: a prospective 10-year study // Aliment. Pharmacol. Ther. — 2001. — 15. — 1795-806.

Kuipers E.J., Lundell L., Klinkenberg-Knol E.C. et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication // N. Engl. J. Med. — 1996. — 334. —

-22.

Lamberts R., Brunner G., Solcia E. Effects of very long (up to 10 years) proton pump blockade on human gastric mucosa // Digestion. — 2001. — 64. — 205-13.

Lundell L., Miettinen P., Myrvold H.E. et al. Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd Study Group // Gastroenterology. — Aug. 1999. — 117(2). — 319-26.




DOI: https://doi.org/10.22141/2308-2097.3.49.2013.86340

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 GASTROENTEROLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru