Changes in Expression of MUC2, MUC3, MUC4, TFF3 of Colonic Mucosa in Patients with Ulcerative Colitis

A.E. Dorofeyev, I.V. Vasilenko, O.A. Rassokhina


The aim of this study was to evaluate the changes in expression of mucins (MUC2, MUC 3, MUC 4) and trefoil peptide (TFF3) of colonic mucus barrier in patients with ulcerative colitis (UC). 49 patients with left-side UC in the acute stage were examined. All patients underwent endoscopic examination of colonic mucosa with biopsy and morphological study of biopsy sample, determination of expression of MUC2, MUC3, MUC4, TFF3. Changes in colonic mucus barrier of patients with UC indicate disorder in mucus production, expression of mucins and their properties, as well as severity
of UC.


ulcerative colitis; colonic mucus barrier


Intestinal barrier dysfunction in inflammatory bowel diseases / M.A. McGuckin, R. Eri, L.A. Simms et al. // Inflamm. Bowel Dis. — 2009. — № 15. — Р. 100-113.

Role of intestinal mucins in innate host defense mechanisms against pathogens / Р. Dharmni, V. Srivatava, V. Kissoon-Singh et al. // J. Innate Immun. — 2009. — № 1. — Р. 123-135.

Perez-Vilar J. Mucin granule intraluminal organization / J. Perez-Vilar // Am. J. Respir. Cell Mol. Biol. — 2008. — № 36(2). — Р. 183-190.

Kim Y.S. Intestinal goblet cells and mucins in health and disease: recent insights and progress / Y.S. Kim, S.B. Ho // Curr. Gastroenterol. Rep. — 2010. — № 12. — P. 319-330.

Linden S.K. Mucin dynamics in intestinal bacterial infection / S.K. Linden, T.H.J. Florin, M.A. McGuckin // PLoS ONE. — 2008. — V. 3(12). — P. 3952-3966.

MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications / A. Handra-Luca, G. Lamas, J.C. Bertrand et al. // Am. J. Surg. Pathol. — 2005. — № 29. — Р. 881-889.

Copyright (c) 2016 GASTROENTEROLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта