Effect of Genetic Polymorphism on the Formation of Nonalcoholic Fatty Liver Disease

O.Ya. Babak, Ye.V. Kolesnikova, І.V. Shut, Ye.G. Кurinnaya, К.A. Sytnic

Abstract


The article deals with the results showing the existence of the preconditions for the formation of non-alcoholic fatty liver disease (NAFLD) in patients with metabolic disorders. This is due to reliable association of alleles and genotypes of polymorphic marker of adiponectin gene-1 (ADIPOR1) in patients with NAFLD. It is found that the SNP in the promoter of the gene ADIPOR1 is associated in patients with NAFLD with high content of fat in the liver, development of insulin resistance, and more high levels of glycosylated hemoglobin, and gamma-glutamyl transpeptidase. Knowing the features of genotype of patients with NAFLD is required for selection of individualized treatment algorithm.


Keywords


nonalcoholic fatty liver disease; adipocytokines; adiponectin receptors; ADIPOR1 gene polymorphism

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DOI: https://doi.org/10.22141/2308-2097.1.47.2013.86244

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