Immunomorphological Features of Changes of the Local Gastric Mucosal Homeostasis in Chronic HP-Associated Gastritis in Children after Eradication Therapy

O.Ye. Abaturov, N.Yu. Zavgorodnya

Abstract


The article deals with the results of standard morphological, immunohistochemical study of gastric mucosa biopsy specimens and beta-defensin-2 production in children with chronic HP-associated gastritis taking into account the CagA-status before and after HP eradication, modificated by cholecalciferol. The increase of the treatment efficiency due to anti-inflammatory, immunomodulatory and antiproliferative effects of cholecalciferol have been shown.


Keywords


chronic gastritis; HP-infection; CagA-gene; mucosal immune cells; proliferative activity; beta-defensins; eradication; cholecalciferol

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DOI: https://doi.org/10.22141/2308-2097.1.47.2013.86235

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