Changes of the Rheological Bile Properties in Patients with Nonalcoholic Fatty Liver Disease in Combination with Hyperuricemia

A.S. Svintsitsky, N.P. Kozak, O.V. Barabanchyk

Abstract


In this work we have analyzed research results of colloidal properties of bile, biochemical parameters in patients with nonalcoholic fatty liver disease in combination with hyperuricemia. During the study it was found that on the background of increased uric acid levels, there observed violation in the spectrum of bile acids, increased levels of cholic and deoxycholic acid, reduced level of taurine acid. Imbalance between these indicators and the oxidation of bile leads to increase in bile lithogenic properties, that, in turn, contributes to the formation of gallstones. The use of ursodeoxycholic acid, rosuvastatin and allopurinol in doses, indicated in the survey, in patients with nonalcoholic fatty liver disease in combination with hyperuricemia promotes improvement of clinical symptoms, normalization of biochemical parameters, as well as normalization in the spectrum of bile acids.

Keywords


nonalcoholic fatty liver disease; hyperuricemia; biliary sludge; bile acids; ursodeoxycholic acid

References


Драпкина О.М. Неалкогольная жировая болезнь печени — современный взгляд на проблему / О.М. Драпкина, В.И. Смирин, В.Т. Ивашкин // Лечащий врач. — 2010. — № 5. — С. 57-61.

Мехтиев С.Н. Неалкогольная жировая болезнь печени: клиника, диагностика, лечение / С.Н. Мехтиев, В.Б. Гриневич, Ю.А. Кравчук // Лечащий врач: Гастроэнтерология. — 2008. — № 2. — С. 29-37.

Палій І.Г. Неалкогольна жирова хвороба печінки у контексті метаболічного синдрому: діагностика та лікування в амбулаторній практиці / І.Г. Палій, С.В. Заїка, А.В. Ліфанов // Український медичний часопис. — 2012. VII/VIII. — № 4 (90). — С. 34-39.

Соломенцева Т.А. Неалкогольный стеатогепатит: механизмы развития, диагностика, лечение // Т. А. Соломенцева // Сучасна гастроентерологія. — 2004. — № 6. — С. 25-29.

Фадеенко Г.Д. Неалкогольная жировая болезнь печени при метаболическом синдроме: как лечить / Г.Д. Фадеенко, Е.В. Колесникова // Сучасна гастроентерологія. — 2009. — № 1 (45). — С. 75-81.

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity / J.D. Browning, L.S. Szczepaniak, R. Dobbins [et al.] // Hepatology. — 2004. — № 40 (6). — Р. 1387-1395.

Relationship between nonalcoholic fatty liver disease and metabolic syndrome / S.H. Chen, F. He, H.L. Zhou [et al.] // J. Dig. Dis. — 2011. — № 12 (2). — Р. 125-130.

Feig D.I., Kang D.H., Johnson R.J. Uric Acid and Cardiovascular Risk // N. Engl. J. Med. — 2008. — № 359 (17). — Р. 1811-1821.

High prevalence of metabolic complications in patients with non-alcoholic fatty liver disease / I. Friis-Liby, F. Aldenborg, P. Jerlstad [et al.] // Scand. J. Gastroenterol. — 2004.—№ 39 (9). — Р. 864-869.

Musso G. Non-alcoholic fatty liver disease from pathogenesis to management: an update / G. Musso, R. Gambino, M. Cassader // Obesity Reviews. — 2010. — Volume 11, Issue 6. — Р. 430-445.

The relationship between normal serum uric acid and nonalcoholic fatty liver disease / Hwang I.-C., Suh S.-Y., Suh A.R., Ahn H.-Y. // Journal of Korean Medical Science. — 2011. — № 26 (3). — Р. 386-391.

Patterson R.A. Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid / R.A. Patterson, E.T.M. Horsley, D.S. Leake // Journal of Lipid Research. — 2003. — № 44 (3). — Р. 512-521.

Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men / S. Ryu, Y. Chang, S.-G. Kim [et al.] // Metabolism. — 2011. — № 60 (6). — Р. 860-866.

Targher G. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease / G. Targher, C.P. Day, E. Bonora // N. Engl. J. Med. — 2010. — № 363 (14). — Р. 1341-1350.

High serum uric acid increases the risk for nonalcoholic fatty liver disease: a prospective observational study / C. Xu, C. Yu, L. Xu [et al.] // PLoS ONE. — 2010. — № 5 (7). — Р. 11578.




DOI: https://doi.org/10.22141/2308-2097.3.53.2014.82112

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 GASTROENTEROLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru