The Content of NO Metabolites in the Gastric Juice of Patients with Chronic Reflux Gastritis

A.N. Kovalenko

Abstract


To estimate the role of nitro compounds in pathogenesis of gastric mucosa lesion, the gastric juice concentrations of nitrites and nitrates have been investigated in 65 patients with chronic reflux gastritis. Their marked increase has been detected in the most of patients, especially in atrophic and dysplastic changes in patients with duodenogastric reflux against the background of postcholecystectomy syndrome. Pathological concentrations of nitrates and nitrites in the gastric juice are tightly associated with the H.pylori infection, increase in the biliary acids level, hypergastrinemia. This can play an important role in the development and progression of chronic reflux gastritis and gastrocancerogenesis.


References


Бабак О.Я. Желчный рефлюкс: современные взгляды на патогенез и лечение / О.Я. Бабак // Сучасна гастроентерологiя. — 2003. — № 1(11). — С. 28-30.

Харченко Н.В. Гастроентерологія / Н.В. Харченко, О.Я. Бабак. — К., 2007. — 720 с.

Горячковский A.M. Клиническая биохимия / A.M. Горячковский. — Одесса: Астропринт, 1998. — С. 474.

Effects of reflux on gastric mucosal lesions in patients with dyspepsia or chronic gastritis / S.L. Chen, J.-Z. Mo, Z.J. Cao [et al.] // World J. Gastroenterol. — 2005. — Vol. 11, № 18. — P. 2834-2837.

Correlation between duodenogastric reflux and remnant gastritis after distal gastrectomy / K. Fukuhara, H. Osugi, N. Takada [et al.] // Hepatogastroenterology. — 2004. — Vol. 51, № 58. — P. 1241-1244.

Kawiorski W. Current diagnosis of gastroduodenal reflux and biliary gastritis / W. Kawiorski, R.M. Herman, J. Legiitko // Przegl. Lek. — 2001. — Vol. 58, № 2. — P. 90-94.

Lin J.K. A study of diagnosis of primary biliary reflux gastritis / J.K. Lin, R.J. Hu, C.J. Li // Zhongua Nei Ke Za Zhi. — 2003. — Vol. 42, № 2. — P. 81-83.

Pathogenic effects of primary duodenogastric reflux on gastric mucosa of children / Ma M., Chen J., Zhang Y.Y. [et al.] // Zhonghua Er Ke Za Zhi. — 2007. — Vol. 121, № 11. — E2381-2386.

Sobala G.A.L., O’Connor H.J., Dewar E.P. Bile reflux and intestinal metaplasta in gastric mucosa / G.A.L. Sobala, H.J. O’Connor, E.P. Dewar // J. Clin. Pathol. — 1993. — Vol. 46. — P. 235-240.

Thun M.J. Inflammation and cancer: an epidemiological perspective / M.J. Thun, S.J. Henley, T. Gansler // Novartis Found Symp. — 2004. — № 256. — P. 6-21.

Vaezi M.F. Duodenogastroesophageal reflux and methods to monitor nonacidic reflux / M.F. Vaezi, J.E. Richter // Am. J. Med. — 2001. — № 111 (Suppl. 8А). — P. 160S-168S.

Alkaline reflux gastritis: early and late results of surgery / B. Zobolas, G.H. Sakorafas, I. Kouroukli [et al.] // World J. Surg. — 2006. — Vol. 30, № 6. — P. 1043-1049.




DOI: https://doi.org/10.22141/2308-2097.4.54.2014.81993

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