Morphofunctional State of Esophageal Mucosa in Patients with Gastroesophageal Reflux Disease Depending on the Nutritional Status of Patients

H.D. Fadieienko, V.Yu. Halchinska, I.E. Kushnir, V.M. Chernova, N.V. Yefimova, A.S Shapkin


We have studied morphofunctional state of esophageal mucosa in 57 patients with gastroesophageal reflux disease (GERD) with normal (body mass index (BMI) — 18.5–24.9 kg/m2) and excessive (BMI over 25 kg/m2) body weight. A histologic and morphometric study of esophageal mucosa, immunohistochemical analysis of the expression of apoptosis marker CD95 and inflammatory marker cyclooxygenase-2 (COX-2) were carried out. In reflux esophagitis, most characteristic are changes in multilayered epithelium — hyperkeratosis, parakeratosis, proliferation of basal cells and acanthosis. At that, significant differences in morphometric characteristics of patients with normal BMI and overweight were not found. The development of reflux esophagitis was associated with violations of pro-apoptotic ability of esophageal mucosa cells and increased expression of COX-2, most significant in patients with high BMI. Detected disorders may determine the mechanisms of complicated course of GERD in these patients.


gastroesophageal reflux disease; esophageal mucosa; markers of apoptosis; cyclooxygenase-2


Звенигородская Л.А. Клинико-морфологические особенности гастроэзофагеальной рефлюксной болезни у пациентов с абдоминальным ожирением / Л.А. Звенигородская, Е.Ю. Бондаренко, С.Г. Хомерики // Consilium medicum. — 2010. — Т. 12, № 8. — С. 5-7.

Вміст гормонів адипоцитарного походження у хворих на гастроезофагеальну хворобу з різним трофологічним статусом / Г.Д. Фадєєнко, В.Ю. Гальчінська, І.Е. Кушнір [та ін.] // Сучасна гастроентерологія. — 2013. — № 5(73). — С. 55-58.

Anand G. Gastroesophageal reflux disease and obesity / G. Anand, P.O. Katz // Rev. Gastroenterol. Disord. — 2008. — № 8(4). — Р. 233-9.

Microscopic esophagitis in gastro-esophageal reflux disease: individual lesions, biopsy sampling, and clinical correlations / L. Mastracci, P. Spaggiari, F. Grillo [et al.] // Virchows. Arch. — 2009. — Vol. 454. — P. 31-39.

Ayhani S. Isisagi Immunohistochemical analysis of Ki-67, p53 and Bcl-2 expression related to histological features in gastroesophageal reflux disease / S. Ayhani, O. Aknalbanti // Turk. J. Gastroenterol. — 2010. — Vol. 21(3). — Р. 199-205.

Bile salts differentially sensitize esophageal squamous cells to CD95 (Fas/Apo-1 receptor) mediated apoptosis / S. Naran, P. Abrams, P.Q. de Oliveira [et al.] // J. Surg. Res. — 2011. — Vol. 171, № 2. — P. 504-509.

Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells / S.F. Yang, M.K. Chen, Y.S. Hsieh [et al.] // J. Biol. Chem. — 2010. — Р. 29808-16.

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumor microenvironment / A. Greenhough, H.J. Smartt, A.E. Moore [et al.] // Carcinogenesis. — 2009. — Vol. 30(3). — Р. 377-86.

Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett`s esophagus, and esophageal adenocarcinoma / H.R. Ferguson, C.P. Wild, L.A. Anderson [et al.] // Сancer Epidemiol. Biomarkers Prev. — 2008. — Vol. 17(3). — Р. 727-31.

Tatsuguchi A. Cyclooxygenase expression correlates with angiogenesis and apoptosis in gastric cancer tissue / A. Tatsuguchi, K. Matsui, Y. Shinji // Hum. Pathol. — 2004. — № 35. — Р. 95.

Wallace J.L. Emerging roles for cyclooxygenase 2 in gastrointestinal mucosal defense / J.L. Wallace, P.R. Devchand // Br. J. Pharmacol. — 2005. — № 145(3). — Р. 275-287.

Abdalla S.I. Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells / S.I. Abdalla, I.R. Sanderson, R.C. Fitzgerald // Carcinogenesis. — 2005. — Vol. 26(9). — Р. 1627-1633.

The association of gastric leptin with esophageal inflammation and metaplasia / F. Francois, J. Roper, A.J. Goodman [et al.] // Gut. — 2008. — № 57. — Р. 16-24.

Bresalier COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signaling pathways in Barrett’s esophagus and esophageal adenocarcinoma / Song Shumei, Guha Sushovan, Liu Kaifeng [et al.] // Gut. — 2007. — № 56. — Р. 1512-1521.

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