Modern Approaches to an Initial and Anti-Relapse Treatment of Gastroesophageal Reflux Disease

S.M. Tkach


The article deals with the modern approaches to an initial and anti-relapse treatment of gastroesophageal reflux disease (GERD), based on the recommendations of the last two American consensus. According to these data, the main drugs for the treatment of GERD are proton pump inhibitors (PPIs), which are divided into the first- and second-generation drugs and can be used in standard doses, as well as in double- and half-doses. Second-generation drugs are more effective and safe as they less dependent on CYP2C19 polymorphism of. It is concluded that in most cases, the initial treatment should begin with the use of standard or double-doses of PPI, and supporting one — with standard or half-doses used for a variety of schemes — constant, intermittent or therapy «on demand». The best preparation for a long-term treatment of GERD, especially if it is necessary to take other drugs, is pantoprazole.


gastroesophageal reflux disease; proton pump inhibitors; initial and anti-relapse treatment


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