New Epigenetic Pathway of Carcinogenesis Associated with Helicobacter Pylori

S.I. Klymniuk, E.M. Kovanova, M.S. Tvorko

Abstract


New epigenetic pathway of Helicobacter pylori carcinogenesis is initiated by trigger oncogenes of the bacteria. The main mechanism of carcinogenesis — tyrosine kinase phosphorylation with excessive activation of tyrosine kinases and activation of MAPK ERK signaling pathways of normal cell proliferation, that disturbs normal proliferation and leads to uncontrolled cell growth, transformation and, as a result, to tumorigenesis.


Keywords


epigenetic; genetic; carcinogenesis; oncogenes; Helicobacter pylori

References


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DOI: https://doi.org/10.22141/2308-2097.3.57.2015.81534

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