Resistin as a Marker of Liver Function Disorder in Combined Course of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

L.V. Zhuravliova, O.V. Ohnieva


The objective of the study — to assess the correlation between resistin and indexes of the functional state of the liver in patients with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (DM) and with their combination. Materials and methods. 110 patients were examined, among them 20 patients with NAFLD, 20 patients with DM type 2 and 70 patients with comorbidity (NAFLD + DM type 2), they were divided into 2 subgroups — 20 patients with normal body weight and 50 obese patients. The control group consisted of 20 apparently healthy individuals. Comprehensive clinical, laboratory (with determination of indicators of protein, pigment, enzyme and carbohydrate metabolism, resistin level), instrumental (ultrasound of the liver and liver biopsy (8 patients)) examinations were carried out. Results. Significant increase in plasma resistin levels in patients with comorbidity was revealed. Significant correlations between resistin levels and indicators of the functional state of the liver in these patients were established. Conclusion. In patients with NAFLD, DM type 2 and their combination, especially with concomitant obesity, there is an imbalance of fatty tissue products, a sign of which is the increase of resistin level. The relationship between resistin and indicators of the functional state of the liver mainly in the subgroup with comorbid disorders and obesity give reason to believe that hormone and metabolic disorders that affect liver function activate and worsen in obesity.


non-alcoholic fatty liver disease; type 2 diabetes mellitus; obesity; resistin


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