The Role of Adipocytokines in Pancreatic Remodeling in Chronic Pancreatitis

L.V. Zhuravliova, Yu.O. Shekhovtsova

Abstract


The article analysed the data about the role of adipocytokines in pancreatic remodeling in chronic pancreatitis. Data, obtained by generalizing the current literature, enable to identify the role of some adipocytokines (apelin, tumor necrosis factor α) in the development and progression of the pathophysiological processes in the pancreas, especially in regard to the mechanism of chronic pancreatitis. Adipocytokines being studied play a role in carbohydrate and lipid metabolism disorders, promote the induction of inflammation, tissue maladaptive hypertrophy, the onset of steatosis, fibrosis of the pancreas and have an impact on the various stages of the pathogenesis of chronic pancreatitis. We should pay close attention to the diagnostic role of cytokines that can help to develop new algorithms for non-invasive diagnosis of chronic pancreatitis.


Keywords


adipocytokines; pancreatic remodeling; chronic pancreatitis

References


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DOI: https://doi.org/10.22141/2308-2097.2.56.2015.81501

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