Effect of Functional Disorders of the Biliary Tract on the Peculiarities of Lipid Metabolism in Children with Hepatic Steatosis
Purpose. To investigate peculiarities of lipid metabolism in hepatic steatosis among children with biliary dyskinesia. Material and methods. The study involved 31 children with biliary dyskinesia aged 10–17 years old. Patients were divided into four groups: the 1st group consisted of 8 children with biliary normokinesia without steatosis; the 2nd group consisted of 11 children with biliary hypokinesia without steatosis; 3rd group consisted of 6 children with biliary normokinesia and steatosis and the 4th group involved 6 with biliary dyskinesia and steatosis. Such biochemical parameters as total cholesterol, triglycerides, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol levels and atherogenic coefficient were calculated. Findings. The characteristics of serum lipids pattern in children with liver steatosis and functional disorders of gallbladder were studied. Isolated hypercholesterolemia with IIa type of dislipoproteinemia and combined hypercholesterolemia with IIb type of dislipoproteinemia were the most frequent types of dislipoproteinemia among observed patients. It was revealed that dyslipidemia in children with gallbladder hypokinesia was characterized by elevated serum triglycerides, low density lipoprotein-cholesterol level and atherogenic coefficient. Some patients with steatosis had significant increased high-density lipoproteins and very low density lipoproteins. That caused increasing of atherogenic properties while other lipoprotein fractions remained at normal level. Originality. Existence of different ways of hepatic steatosis development in children with biliary dyskinesia based on alterations of bile genesis and excretion was suggested. Practical value. A regular control of triglycerides, high density lipoproteins and very low density lipoproteins levels in blood serum in children with functional biliary disorders of hypokinetic type and risk of steatosis development was proposed. These biochemical parameters may be additional early markers of the lipid and lipoprotein metabolism disorders.
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