Effect of Functional Disorders of the Biliary Tract on the Peculiarities of Lipid Metabolism in Children with Hepatic Steatosis

Y.M. Stepanov, N.Y. Zavgorodnya, S.O. Babiy, I.A. Klenina


Purpose. To investigate peculiarities of lipid metabolism in hepatic steatosis among children with biliary dyskinesia. Material and methods. The study involved 31 children with biliary dyskinesia aged 10–17 years old. Patients were divided into four groups: the 1st group consisted of 8 children with biliary normokinesia without steatosis; the 2nd group consisted of 11 children with biliary hypokinesia without steatosis; 3rd group consisted of 6 children with biliary normokinesia and steatosis and the 4th group involved 6 with biliary dyskinesia and steatosis. Such biochemical parameters as total cholesterol, triglycerides, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol levels and atherogenic coefficient were calculated. Findings. The characteristics of serum lipids pattern in children with liver steatosis and functional disorders of gallbladder were studied. Isolated hypercholesterolemia with IIa type of dislipoproteinemia and combined hypercholesterolemia with IIb type of dislipoproteinemia were the most frequent types of dislipoproteinemia among observed patients. It was revealed that dyslipidemia in children with gallbladder hypokinesia was characterized by elevated serum triglycerides, low density lipoprotein-cholesterol level and atherogenic coefficient. Some patients with steatosis had significant increased high-density lipoproteins and very low density lipoproteins. That caused increasing of atherogenic properties while other lipoprotein fractions remained at normal level. Originality. Existence of different ways of hepatic steatosis development in children with biliary dyskinesia based on alterations of bile genesis and excretion was suggested. Practical value. A regular control of triglycerides, high density lipoproteins and very low density lipoproteins levels in blood serum in children with functional biliary disorders of hypokinetic type and risk of steatosis development was proposed. These biochemical parameters may be additional early markers of the lipid and lipoprotein metabolism disorders.


lipid metabolism; liver steatosis; biliary functional disorders; children


Rafiq N., Younossi Z.M. Nonalcoholic fatty liver disease: a practical approach to evaluation and management. Clinics in Liver Disease, 2009, issue 13, pp. 249–266.

Colak Y., Bozbey G., Erim T., Caklili O. T., Ulasoglu C., Senates E., Mutlu H. H., Mesci B., Doğan M. S., Tasan G., Enc F.Y., Tuncer I. Impaired Gallbladder Motility and Increased Gallbladder Wall Thickness in Patients with Nonalcoholic Fatty Liver Disease [Electronic resource], Journal of Neurogastroenterology and Motility, 2016, Mode of access.:

Berezenko V. S., Mykhailiuk Kh. Z., Dyba M. B., Tkalyk O. M.. Prychyny rozvytku, diahnostyka ta pidkhody do likuvannia steatozu pechinky ta nealkoholnoho steatohepatytu u ditei [Causes, dignostics and strategies of treating fatty liver disease and nonalcoholic steatohepatitis in children]. Sovremennaya pediatriya [Modern pediatrics], 2014, issue 4, pp. 119–125.

World Health Organization. Media centre, Factsheet, [Electronic resource], 2012, Mode of access.:

Skybchik V.A., Onischuk U.I. Nealkoholna zhyrova hvoroba pechinky: suchasni pidhody do diahnostyky i likuvania [Non-alcoholic fatty liver diseases: modern attachments in diagnosis and treatment]. Mystetstvo likuvania [Art of treatment], 2014, issue 2(108), pp. 6–9.

Gromnatska N. M. Monitoring chastity metabolichnoho syndrome ta osoblyvosti osnovnyh yoho kryteriiv u ditey [Monitoring of metabolic syndrome frequency and its main criteria in childen]. Bukovinski medychny visnyk [Bucovina Medical Visnyk], 2014, issue 18(3), pp. 57–61.

Imajo K., Yoneda M., Kessoku T., Ogawa Y., Maeda S., Sumida Y., Hyogo H., Eguchi Y., Wada K., Nakajima A. Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. International Journal Molecular Science, 2013, issue 14, pp. 21833–21857.

Yeshchenko A. V. Vplyv funktsionalnykh porushen biliarnoho traktu na stan pechinky u pidlitkiv [Impact of functional disorders of biliry tracts on liver condition in adolescents]. Hastroenterolohiia [Gastroenterology], 2013, issue 2, pp. 56–64.

Atamanalp S. S., Keles M. S., Atamanalp R. S., Acemoglu H., Laloglu E.. The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration. Pakistan Journal Medicine Science, 2013, issue 29, pp. 187–190.

Nassir F., Ibdah J. A. Role of Mitochondria in Nonalcoholic Fatty Liver Disease. International Journal Molecular Science, 2014, issue 15, pp. 8713–8742.

Liew P. L., Lee Y. C., Lin Y. C., Lee T. S., Lee W.J., Wang W., Chien C. W. Comparison of artificial neural networks with logistic regression in prediction of gallbladder disease among obese patients. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2007, issue 39, pp. 356–362.

Koller T., Kollerova J., Hlavaty T., Huorka M., Payer J. Cholelithiasis and markers of nonalcoholic fatty liver disease in patients with metabolic risk factors. Scandinavian Journal of Gastroenterology, 2012, 47, pp. 197–203.

Yilmaz Y., Ayyildiz T., Akin H., Colak Y., Ozturk O., Senates E., Tuncer I., Dolar E.. Gallstone disease does not predict liver histology in nonalcoholic fatty liver disease. Gut and Liver, 2014, issue 8, pp. 313–317.

Goncharenko N. I. Motorno-evakuatornaya funktsiya zhelchnogo puzyrya u detey s khronicheskimi gepatitami i portalnoy gipertenziey [The gallbladder motility on children with chronic hepatitis and portal hypertension]. Perinatologiya i pediatriya [Prenatology and pediatrics]. – 2011. – issue 1. – С. 76–79.

Petri A., Sebin K. Naglyadnaya statistika v meditsine [Visual statistic in medicine]. Moscow, Geotar-Med, 2003. 144 p.

Yerin Yu.S. Informatsiinyi biuleten dlia khvorykh. Hiperlipidemiia (pidvyshchennia zhyriv u krovi) [News-letter for patients. Hyperlipidemia (lipid increasing in blood)]. Ukrainskyi zhurnal dytiachoi endokrynolohii [Ukrainian Journal of pediatric endocrinology], 2014, issue 4, pp. 73–78.

Kawano Y., Cohen D. E. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. Journal Gastroenterology, 2013, issue 48, P. 434–441.

Mitchenko O. I., Lutai M. I. Dyslipidemii: Diahnostyka, profilaktyka ta likuvannia [Dyslipidemias. Diagnosis prophylactic and treatment]. Kiev, Chetverta khvylia, 2007. 56 p.

Tsai C. J. Steatocholecystitis and fatty gallbladder disease. Digestive Diseases and Sciences, 2009, issue 54, pp. 1857–1863.

Goldblatt M. I., Swartz-Basile D. A., Al-Azzawi H. H., Tran K. Q., Nakeeb A, Pitt H. A. Nonalcoholic Fatty gallbladder disease: the influence of diet in lean and obese mice. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract, 2006, issue 10, pp. 193–201.

Alexopoulos N., Katritsis D., Raggi P. Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis. Atherosclerosis, 2014, issue 233, pp. 104–112.

Jung U. J., Choi M. S. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. International Journal of Molecular Sciences, 2014, issue 15, pp. 6184–6223.

Enjoji M., Yasutake K., Kohjima M., Nakamuta M. Nutrition and Nonalcoholic Fatty Liver Disease: The Significance of Cholesterol [Electronic resource]. International Journal of Hepatology, 2012, Mode of access.: ID 925807

Trauner M., Claudel T., Fickert P., Moustafa T., Wagner M. Bile Acide as Regulators of Hepatic Lipid and Glucose Metabolism. Digestive Disease, 2010, issue 28, pp. 220–224.

Tabas I. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. Journal Clinical Investigations, 2002, issue 110, P. 905–911.

Copyright (c) 2016 GASTROENTEROLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта