Exocrine Pancreatic Insufficiency in Diabetes Mellitus: Incidence, Pathogenesis, Diagnosis and Treatment

S.M. Tkach

Abstract


The article deals with exocrine pancreatic insufficiency (EPI), which is being detected in a significant number (30–50 %) of patients with diabetes mellitus (DM) type I and II and could potentially affect the compensation of DM. Enzyme replacement therapy should be considered as one of the most promising treatments in patients with DM. This therapy is preferably to be carried out in accordance with clinical guidelines set out in the recent consensuses, however, with higher doses of modern fourth-generation enzyme preparations such as Pangrol® 25000. Additional methods of treatment for EPI in patients with DM are correction of nutritional status using appropriate diet, as well as vitamin replacement therapy.


Keywords


exocrine pancreatic insufficiency; diabetes mellitus; enzymes; enzyme replacement therapy

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DOI: https://doi.org/10.22141/2308-2097.1.55.2015.80372

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