Influence of Simvastatin and Interleukin 1 Receptor Antagonist on Expression of Aryl Hydrocarbon Receptors Under Experimental Acute Ileitis

O.S. Zherebiatiev, O.M. Kamyshnyi


Aryl hydrocarbon receptor (AhR) — transcription factor activated by a large number of environmental agents, and may play a role in the pathogenesis of inflammatory bowel diseases in humans and mouse models. We have investigated the possibility of using simvastatin and interleukin 1 receptor antagonist for pharmacological correction of acute ileitis in rats, with a focus on the studying intensity of AhR expression by lymphocytes of the small intestine. The AhR-immunopositive lymphocytes were determined by means of indirect immunofluorescence technique using monoclonal rat antibodies. We have established that development of ileitis was associated with changes in the amount of AhR+ lymphocytes and their density on immunopositive cells. Drug administration during the development of experimental pathology was accompanied by changes in the expression of AhR and their density on lymphocytes.


experimental ileitis; inflammatory bowel diseases; aryl hydrocarbon receptor


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