Features of the Diagnosis and Treatment of Acid-Related Disease in Patients with Diabetes Mellitus
DOI:
https://doi.org/10.22141/2308-2097.3.61.2016.79161Keywords:
peptic ulcer disease, gastroesophageal reflux disease, eradication of H.pylori, diabetes mellitus, pantoprazoleAbstract
The article considers the problem of the combined course of acid-related disorder of the gastrointestinal tract and diabetes mellitus (DM). The attention is paid to the fact that in most cases the treatment of gastroesophageal reflux disease and peptic ulcers in patients with diabetes mellitus should be carried out not as a proton pump inhibitor monotherapy, but as a comprehensive and differentiated treatment, taking into account etiological and pathogenetic features of the disease. When choosing the components of triple or quadruple therapy for the eradication of H.pylori in patients with DM among the group of proton pump inhibitors, it is desirable to give preference to pantoprazole (Zovanta). Pantoprazole does not interact with clarithromycin — basic antibiotic of H.pylori therapy. H.pylori therapy based on pantoprazole reduces the likelihood of side effects and increases the effectiveness of treatment.
References
Алексеенко С.А., Гордиенко С.А., Коротун В.М., Никонов Е.Л. Сравнительная эффективность различных схем антихеликобактерной терапии у больных сахарным диабетом 2-го типа // Рос. журн. гастроэнтерол., гепатол. и колопроктол. — 2001. — № 2 (Прил. 13). — С. 10-12.
Зиннатуллин М.Р., Циммерман Я.С., Трусов В.В. Сахарный диабет и язвенная болезнь // Экспериментальная и клиническая гастроэнтерология. — 2003. — № 5. — С. 17-24.
Колесникова Е.В. Диабетическая гастропатия: современный взгляд на этиопатогенез, диагностику и лечение // Здоровье Украины. — 2007. — № 7/1. — С. 62-63.
Федорченко Ю.Л., Коблова Н.М., Обухова Г.Г. Особенности течения язвенной болезни желудка и двенадцатиперстной кишки у больных сахарным диабетом // Врач. — 2001. — № 7. — С. 28-30.
Abraham N.S., Hlatky M.A., Antman E.M. et al. ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. A report of the American college of cardiology foundation task force on expert consensus documents // J. Am. Coll. Cardiol. — 2010. — 56 (24). — 2051-2066.
Banerjee S., Weideman R.A., Weideman M.W. et al. Effect of concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention // Am. J. Cardiol. — 2011. — 107. — 871-878.
American Diabetic Association. Diagnosis and classification of diabetes mellitus // Diabetes Care. — 2009. — 32 (Suppl.). — S62-267.
Anastasios R., Goritsas C, Paramihail C. et al. Helicobacter pylory infection in diabetic patients: prevalence and endoscopic findings // Eur. J. Int. Med. — 2002. — V. 13 (6). — P. 376-379.
Emery M.G., Fisher J.M., Chien J.Y. et al. CYP2E1 activity before andafter weight loss in morbidly obese subjects with nonalcoholicfatty liver disease // Hepatology. — 2003. — 38. — 428-435.
FDA reminder to avoid concomitant use of Plavix (clopidogrel) and omeprazole; www.fda.gov/Drugs/DrugSafety/ucm231161. htm
Fitton A., Wiseman L. Pantoprazole. A review of its pharmacological properties and therapeutic use in acid-related disorders // Drugs. — 1996. — 51, 3. — 460-482.
Hagymási K., Müllner K., Herszényi L., Tulassay Z. Update on the pharmacogenomics of proton pump inhibitors // Pharmacogenomics. — 2011. — 12 (6). — 873-888.
Johnson D.A. Concomitant use of PPIs and antiplatelet therapy // Gastroenterol., Hepatol. — 2011. — 7. — 7-10.
Kotlyar M., Carson S.W. Effects of obesity on the cytochrome P450 enzyme system // Int. J. Clin. Pharmacol. Ther. — 1999. — 37. — 8-19.
Kromer W., Horbach S., Luhmann R. Relative efficacies of gastric proton pump inhibitors: their clinical and pharmacological basis // Pharmacology. — 1999. — 59. — 57-77.
Kwok C.S., Loke Y.K. Effects of proton pump inhibitors on platelet function in patients receiving clopidogrel: a systematic review // Drug Saf. — 2012. — 35. — 127-139.
Leclercq I., Horsmans Y., Desager J.P. et al. Reduction in hepaticcytochrome P‑450 is correlated to the degree of liver fat contentin animal models of steatosis in the absence of inflammation // J. Hepatol. — 1998. — 28. — 410-416.
Li X.-Q., Andersson T.B., Ahlstrom M., Weidolf L. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities // Drug Metab. Dis. — 2004. — 32 (8). — 821-827.
Ogawa R., Echizen H. Drug-drug interaction profiles of proton pump inhibitors // Clin. Pharmacokinet. — 2010. — 49 (8). — 509-533.
Steinijans V., Huber R., Hartmann M. et al. Lack of pantoprazole drug interactions in man: an updated review // Int. J. Clin. Pharmacol. Ther. — 1996. — 34 (1 Suppl.). — S31-S50.
Trifiro G., Corrao S., Alacqua M. et al. Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources // Br. J. Clin. Pharmacol. — 2006. — 62 (5). — 582-590.
Xia H.H.-X., Talley N.J. et al. Helicobacter pylory infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus // Am. J. Gastroenterol. — 2001. — V. 96 (4). — P. 1039-1046.
Wrighton S.A., Thummel K. CYP3A // Levy R.H., Thummel K.E., Trager W.F., eds. Metabolic drug interactions, chapter 10. — Philadelphia: Lippincott Williams &Wilkins, 2000.
Downloads
Issue
Section
License
Copyright (c) 2020 GASTROENTEROLOGY

This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.