Risk Factors for Hepatic Steatosis in Children

Yu.M. Stepanov, N.Yu. Zavhorodnia, O.Yu. Lukianenko, V.B. Yagmur, I.Yu. Skyrda, O.P. Petishko


Nonalcoholic fatty liver disease has become the most common cause of liver disease in children worldwide. Purpose: to identify risk factors (RF) for hepatic steatosis in children. Methods. Thirty two children with gastrointestinal disorders were examined by us. The presence and severity of hepatic steatosis was determined using FibroScan® 502 touch with controlled attenuation parameter (CAP). According to the results of CAP the children were divided into 2 groups: group 1 (basic) — 13 children with steatosis (40.6 %), group 2 (control) — 19 children without steatosis (59.4 %). To determine the risk factors we analyzed a history of life and disease, objective clinical and laboratory examination of patients. Results. Analysis of the age distribution showed that children older than 10 years old dominated in the basic group (RR 3.3; OR 4.0; p = 0.1). Obesity was found in 12 (92.3 %) children in the group with steatosis and in 9 (47 %) children without steatosis. Increased waist circumference values above 95 percentile according to age and sex of a child was observed in 12 (92.3 %) children in the basic group and in 8 (42.1 %) children in the control group (RR 7.2; OR 16.5; p < 0.05). It was found that the presence of pubertal hypothalamic syndrome is associated with risk of hepatic steatosis in children (RR 30.6; OR 4.8; p < 0.05). Discussion. Abdominal type of obesity in combination with diseases of the endocrine system, namely, hypothalamic syndrome should be considered as the leading risk factors for hepatic steatosis in children.


hepatic steatosis; risk factors; children.


Singer C., Stancu P., Coşoveanu S. Non-Alcoholic Fatty Liver Disease in Children. Curr Health Sci J., 2014, no. 40 (3), pp. 170–176.

Alisi A., Feldstein A. E., Villani A. Pediatric nonalcoholic fatty liver disease: a multidisciplinary approach. Nat. Rev. Gastroenterol. Hepatol., 2012, no. 9 (3), pp. 152-61. doi: 10.1038/nrgastro.2011.273.

Chalasani N., Younossi Z., Lavine Joel E. The Diagnosis and Management of Non-Alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology, 2012, no. 55 (6).

Stepanov Y. M. Hepatic steatosis and steatohepatitis - the inevitability of mixed origin. Gastroenterologia [Gastroenterology], 2014, no. 4 (54), pp 136-142 (in Russian).

Stepanov Y. M., Abaturov O.E., Zavgorodnya N.Y., Skirda N. Y. Non-Alcoholic Fatty Liver Disease in Children (part I). Gastroenterologia [Gastroenterology], 2015, no. №2, pp. 99-107.

Tominaga K., Kurata J. H., Chen Y. K. Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey. Dig Dis Sci., 1995, no. 40 (9), pp .2002-9.

Perito E. R., Tsai P. M., Hawley S. Targeted hepatic sonography during clinic visits for detection of fatty liver in overweight children: a pilot study. J. Ultrasound Med., 2013, no. 32, № 4, pp. 637-643.

Pacifico L., Celestre M., Anania C. MRI and ultrasound for hepatic fat quantification:relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease. Acta Paediatr, 2007, no. 96(4), pp 542-7. doi: 10.1371/journal.pone.0137239.

Cho Y., Tokuhara D., Morikawa H. Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan. BMC Pediatr., 2015, no. 15, pp 151. doi: 10.1186/s12887-015-0465-x.

Order of Ministry of Health care of Ukraine "On Approval of protocols treatment for children with endocrine diseases", number 255. Kiev, Publ., 2009. (In Ukrainian).

WHO. The WHO child growth standards website [Online]. 2006.

Berezenko VS, Mikhailyuk H. Z., Diba MB. Causes of diagnosis and treatment approaches steatosis and nonalcoholic steatohepatitis in children - Sovremennaya pedyatrya, no 4(60), pp. 119-125.

Saad V., Wicklow B., Wittmeier K. clinically relevant method to screen for hepatic steatosis in overweight adolescents: a cross sectional study. J. Pediatr Gastroenterol Nutr., 2015, Vol. 57(1), pp. 109-13. doi: 10.1097/MPG.0b013e31829206a0.

Goldschmidt N., Streckenbach C., Dingemann C. Application and limitations of transient liver elastography in children. J Pediatr Gastroenterol Nutr., 2013, no. 57(1), pp. 109-13. doi: 10.1097/MPG.0b013e31829206a0.

Cho Y., Tokuhara D., Morikawa H. Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan. BMC Pediatr., 2015, no. 15, pp. 151. doi: 10.1186/s12887-015-0465-x.

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