Peculiarities of Intestine Motor-Evacuation Function in Patients with Various Forms of Irritable Bowel Syndrome
To assess motor and evacuation function of gastrointestinal tract in irritable bowel syndrome (IBS) several methods can be used. Our aim was to study colonic motility in patients with different variants of IBS using dynamic scintigraphy. Materials and methods. 107 patients with IBS by Rome III criteria (2006) were enrolled. All patients were divided into 4 groups: I group — IBS with constipation (36/107, 33.6 %), II group — IBS with diarrhea (35/107, 32.7 %), III group — unspecified IBS (22/107, 20.7 %), IV group — mixed IBS (14/107, 13.0 %). Dynamic scintigraphy was done using scintillation gamma-room OFECT‑1 and EBM. Medium activity of radiopharmaceutical was taken at a rate of 10 MBq/kg body weight of the patient. Results. The results showed that in case of the IBS with constipation the passage of radiopharmaceutical decreased (increased radioactivity in the abdomen (> 60 %) and asymmetry of the right and left parts of the bowel is < 31 %, p < 0.05 in all cases). As for the IBS with diarrhea the speed of radiopharmaceutical increased (radioactivity in the abdomen is < 60 %, asymmetry of the right and left parts of the bowel is > 2 5 %, p < 0.05 in all cases). No statistically significant motor changes in case of unspecified and mixed variants of IBS were found (p > 0.05). Conclusion. Using dynamic scintigraphy we found expressed slowing of the passage of radiopharmaceutical in IBS patients with constipation (p < 0.05), while in case of IBS with diarrhea the speed of radiopharmaceutical evacuation was increased (p < 0.05). In a case of other variants of IBS no statistically significant changes were detected.
Longstreth G. F.,D. A. Drossman. New developments in the diagnosis and treatment of irritable bowel syndrome Curr. Gastroenterol. Rep, 2002, vol. 4, no 5, pp. 427–434
Irritable bowel syndrome in adults. Diagnosis and management of irritable bowel syndrome in primary care National collaborating centre for nursing and supportive care. London NICE, 2008. No 61. Clinical guideline, 881 p.
Smout A. J. P. M, Akkermans L. M. A. Normal and disturbed motility of the gastrointestinal tract. Petersfield Wrightson Biomed. Pub., 1992. 313 p.
Tokutomi Y., Torihashi S., Tokutomi N., Nishi K. Genetic basis of autonomic gastrointestinal motility and pathophysiological models. 2002, vol, 119, no 4, pp. 227–234.
Buhmann S., Kirchhoff C., Wielage C. [et al.] Visualization and quantification of large bowel motility with functional cine-MRI. Rofo, 2005. vol. 177, no 1, pp. 35–40.
Bennink R., Peeters M., Van den Maegdenbergh V. [et al.] Evaluation of small-bowel transit for solid an d liquid test meal in healthy men and women. Eur. J. Nucl. Med. 1999. Vol. 26, N 12. P. 1560–1566.
Lartigue S., Bizais Y., Bruley des Varanne S. s [et al.] Measurement of gastric emptying, intestinal transit time and colonic filling by scintiscan in healthy subjects. Gastroenterol. Clin. Biol, 1991. vol. 15, no 5, pp. 379–385.
Maurer A. H. Krevsky B. Whole-gut transit scintigraphy in the evaluation of small-bowel and colon transit disorders. Semin. Nucl. Med. 1995, vol. 25, no 4, pp. 326–338.
Mantides A. Gut motility and visceral perception in IBS patients. Annals of Gastroenterology. 2002, vol.15(3), pp.240-247.
Gorard D., Vesselinova-Jenkins D., Gorard, C., Libby G., et al. Migrating motor complex and sleep in health and irritable bowel syndrome. Dig Dis Sci, 1995, nol.40, pp.1383-1389.
Stivland T.. Camillieri M., Vassalo M., et al. Scintigraphic measurement of regional gut transit in idiopathic constipation. Gastroenterology, 1991, vol.101, pp.107-115.
Gorard D., Farthing M. Intestinal motor function in irritable bowel syndrome Dig Dis Sci, 1994, vol.12, pp.72-84.
Trotman M., Price C. Bloated irritable bowel syndrome defined by dynamic 99mTc-bran scan. Lancet. –1986, vol.2, pp.364-366.
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