Features of the Course of the Upper Gastrointestinal Tract Pathology in Patients with Oropharyngeal Candidiasis

I.V. Kushnirenko

Abstract


The article presents the results of studying the sixth scale of comorbidity The Cumulative Illness Rating Scale, which represents the upper digestive tract diseases in patients with oropharyngeal candidiasis compared with patients without fungi and individuals with mild/moderate growth of Candida fungi on the oral mucosa. It was determined that at the same incidence of chronic gastroduodenitis and chronic gastritis, patients with oropharyngeal candidiasis are characterized by the decrease in the incidence of both gastroesophageal reflux disease — by 1.6 and 1.5 times compared with those without fungi and those with mild/moderate growth (p < 0.05 and p < 0.05, respectively), and peptic ulcer with cicatricial deformity of the duodenum — by 2.1 times compared with individuals without fungi (p < 0.05). In the presence of gastroesophageal reflux disease, the risk of oropharyngeal candidiasis in patients was significantly lower (odds ratio (OR) = 0.49, 95% confidence interval (CI) = 0.29–0.83) compared with patients without fungi. Candidiasis of esophagus was diagnosed in one third of patients with oropharyngeal candidiasis, which was significantly higher compared to those without fungi (n = 1) (p < 0.001), and four times higher than in patients with mild/moderate growth (p < 0.001). The high chance of detecting esophageal candidiasis in patients with oropharyngeal candidiasis (OR = 55.00, 95% CI = 7.43–407.07) demonstrates the ability of Candida species, in case of the excessive growth on the oral mucosa, to adhere and germinate in the mucosa of the distal part of the upper gastrointestinal tract. High prognostic assessment of identifying oropharyngeal candidiasis in Helicobacter pylori infection in patients with gastroenterological pathology indicates the unity of pathological processes (OR = 5.76, 95% CI = 2.95–11.26).
Further study of the immune protection under Candida fungi overgrowth in gastroenterological patients will make it possible to explain the features of comorbid status in this pathology.


Keywords


oropharyngeal candidiasis; comorbidity; gastroesophageal reflux disease; peptic ulcer disease; chronic pancreatitis.

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DOI: https://doi.org/10.22141/2308-2097.2.60.2016.74554

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