Features of the Course of the Upper Gastrointestinal Tract Pathology in Patients with Oropharyngeal Candidiasis

I.V. Kushnirenko


The article presents the results of studying the sixth scale of comorbidity The Cumulative Illness Rating Scale, which represents the upper digestive tract diseases in patients with oropharyngeal candidiasis compared with patients without fungi and individuals with mild/moderate growth of Candida fungi on the oral mucosa. It was determined that at the same incidence of chronic gastroduodenitis and chronic gastritis, patients with oropharyngeal candidiasis are characterized by the decrease in the incidence of both gastroesophageal reflux disease — by 1.6 and 1.5 times compared with those without fungi and those with mild/moderate growth (p < 0.05 and p < 0.05, respectively), and peptic ulcer with cicatricial deformity of the duodenum — by 2.1 times compared with individuals without fungi (p < 0.05). In the presence of gastroesophageal reflux disease, the risk of oropharyngeal candidiasis in patients was significantly lower (odds ratio (OR) = 0.49, 95% confidence interval (CI) = 0.29–0.83) compared with patients without fungi. Candidiasis of esophagus was diagnosed in one third of patients with oropharyngeal candidiasis, which was significantly higher compared to those without fungi (n = 1) (p < 0.001), and four times higher than in patients with mild/moderate growth (p < 0.001). The high chance of detecting esophageal candidiasis in patients with oropharyngeal candidiasis (OR = 55.00, 95% CI = 7.43–407.07) demonstrates the ability of Candida species, in case of the excessive growth on the oral mucosa, to adhere and germinate in the mucosa of the distal part of the upper gastrointestinal tract. High prognostic assessment of identifying oropharyngeal candidiasis in Helicobacter pylori infection in patients with gastroenterological pathology indicates the unity of pathological processes (OR = 5.76, 95% CI = 2.95–11.26).
Further study of the immune protection under Candida fungi overgrowth in gastroenterological patients will make it possible to explain the features of comorbid status in this pathology.


oropharyngeal candidiasis; comorbidity; gastroesophageal reflux disease; peptic ulcer disease; chronic pancreatitis.


Kempa H., Sadlak-Nowicka J., Kedzia A. [et al.]. Candida infections of the oral mucosa — ​not only a dental problem // Przegl. Lek. — 2006. — № 63 (5). — ​P. 257-260.

Pedersen L., Nauntofte B., Smidt D. [et al.]. Oral mucosal lesions in older people: relation to salivary secretion, systemic diseases and medications // Oral Dis. — 2015. — № 21 (6). — ​P. 721-729.

Yamamoto A.A.C., de Paula C.R., Dias L.B. [et al.]. Epidemiological and clinical characteristics of nosocomial candidiasis in university hospitals in Cuiaba-Mato Crosso, Brazil // Rev. Iberoam. Micol. — 2012. — № 29 (3). — ​P. 164-168.

Weerasuriya N., Snape J. A study of candida esophagitis in elderly patients attending a district general hospital in the UK // Diseases of the Esophagus. — 2006. — № 19. — ​P. 189-192.

De Nobrega T.M., Jaluul O., Machado A.N. [et al.]. Quality of Life and Multimorbidity of Elderly Outpatients // Clinics. — 2009. — № 64 (1). — ​P. 45-50.

Salvi F., Miller M.D., Grilli A. [et al.]. A Manual of Guidelines to Score the Modified Cumulative Illness Rating Scale and Its Validation in Acute Hospitalized Elderly Patients // J. Am. Geriatr. Soc. — 2008. — № 56 (10). — ​P. 1926-31.

Duggan S.N., Chonchubhair M.N., Lawal O., O’Con­nor D.B., Conlon K.C. Chronic pancreatitis: A diagnostic dilemma // World Journal of Gastroenterology. — 2016. — № 22 (7). — ​P. 2304-2313.

Циммерман Я.С. Нерешенные и спорные проблемы современной гастроэнтерологии (Unsolved and Debatable Issues of Modern Gastroenterology). Глава 4. Язвенная болезнь: актуальные проблемы этиологии, патогенеза, дифференцированного лечения. — ​М.: МЕДпресс-информ, 2013. — 224 с.

Pimentel-Nunes P., Soares J.B., Dinis-Ribeiro M. Toll-Like Receptors as Biomarkers of Gastric Carcinogenesis: Implications for Diagnosis, Prognosis and Treatment // Journal of Cancer Therapy. — 2013. — № 4. — ​Р. 1037-1047.

Zabaleta J. Multifactorial etiology of gastric cancer // Methods Mol. Biol. — 2012. — № 863. — ​Р. 411-435.

Inman K.S., Francis A.A., Murray N.R. Complex role for the immune system in initiation and progression of pancreatic cancer // World Journal of Gastroenterology. — 2014. — № 20 (32). — ​P. 11160-11181.

Xue J., Sharma V., Habtezion A. Immune cells and immune-based therapy in pancreatitis // Immunol. Res. — 2014. — № 58. — ​P. 378-386.

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