Clinical and genetic characteristics of patients with obesity and non-alcoholic fatty liver disease
Keywords:ultrasound steatometry, controlled attenuation parameter, rs1801282 (Pro12Ala) polymorphism of PPAR-γ2 gene
AbstractBackgrounds. Currently, the rs1801282 (Pro12Ala) polymorphism in PPAR-γ2 (peroxisome proliferator-activated receptor gamma) gene is important for the pathogenesis of both obesity and non-alcoholic fatty liver disease (NAFLD). However, the clinical and laboratory characteristics in Ukrainian patients with combined pathology have not yet been studied based on this polymorphism. The purpose was to study the clinical and laboratory features of patients with obesity and NAFLD depending on rs1801282 polymorphism in PPAR-γ2 gene. Materials and methods. The study involved 123 patients with obesity 1–3 classes and NAFLD. All patients underwent a molecular genetic study of rs1801282 polymorphism in PPAR-γ2 gene, as well as anthropometric measurements, laboratory and instrumental examinations (including ultrasound (US) steatometry). Results. The study revealed in patients with CG and GG genotypes rs1801282 polymorphism of PPAR-γ2 gene significantly much higher levels of body mass index (p = 0.03), fasting glucose (p = 0.02), insulin (p < 0.0001), and C-peptide (p = 0.02), ALT (p = 0.04), GGTP (p < 0.0001), total cholesterol (p = 0.03), triglycerides (p = 0.002), low-density lipoprotein cholesterol (p = 0.004), very low-density lipoprotein cholesterol (p = 0.001), atherogenic factor (p < 0.0001), except for levels of CAP (p = 0.002), stimulated insulin (p < 0.0001), serum uric acid (p = 0.008), and high-density lipoprotein cholesterol (p < 0.0001) that were significantly less higher compared to CC genotype. Conclusions. In Ukrainians with a combined course of obesity and NAFLD, the carriers of the G allele rs1801282 polymorphism of PPAR-γ2 gene have been shown to have significant metabolic differences that might be associated with protection against the development of steatosis and type 2 diabetes, however increase cardiovascular risk.
Alonso R, Farías M, Alvarez V, Cuevas A. The Genetics of Obesity. In: Rodriguez-Oquendo A, editor. The Genetics of Obesity. Translational Cardiometabolic Genomic Medicine. London: Elsevier Science Publishing Co Inc; 2016. 161-177 pp.
Goodarzi MO. Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol. 2018 Mar;6(3):223-236. doi:10.1016/S2213-8587(17)30200-0.
Walter S, Mejía-Guevara I, Estrada K, Liu SY, Glymour MM. Association of a Genetic Risk Score With Body Mass Index Across Different Birth Cohorts. JAMA. 2016 Jul 5;316(1):63-9. doi:10.1001/jama.2016.8729.
Loomba R, Schork N, Chen CH, et al; Genetics of NAFLD in Twins Consortium. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec;149(7):1784-93. doi:10.1053/j.gastro.2015.08.011.
Ramos-Lopez O, Milagro FI, Allayee H, et al. Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity. J Nutrigenet Nutrigenomics. 2017;10(1-2):43-62. doi:10.1159/000477729.
Kovalic AJ, Banerjee P, Tran QT, Singal AK, Satapathy SK. Genetic and Epigenetic Culprits in the Pathogenesis of Nonalcoholic Fatty Liver Disease. J Clin Exp Hepatol. 2018 Dec;8(4):390-402. doi:10.1016/j.jceh.2018.04.001.
Wolf Greenstein A, Majumdar N, Yang P, Subbaiah PV, Kineman RD, Cordoba-Chacon J. Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice. J Endocrinol. 2017 Jan;232(1):107-121. doi:10.1530/JOE-16-0447.
Takahashi K, Nakamura H, Sato H, Matsuda H, Takada K, Tsuji T. Four Plasma Glucose and Insulin Responses to a 75 g OGTT in Healthy Young Japanese Women. J Diabetes Res. 2018 Jan 30;2018:5742497. doi:10.1155/2018/5742497.
Gorovenko NG, Prysyazhnyuk VP, Rossokha ZI. Association of Pro12Ala polymorphism of PPAR-γ gene with blood biochemical parameters, cytokine and adypokine profiles, structural and functional parameters of liver in patients with nonalcoholic fatty liver disease. Ukrainian Medical Journal. 2017;5(121):144-147. (in Ukrainian).
Copyright (c) 2020 GASTROENTEROLOGY
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.