Main Article Content
Background. The problem of the development and progression of chronic diffuse liver diseases is currently one of the most important in modern gastroenterology, it has general medical and social significance. The purpose was to determine the features of indicators of the functional state of the liver, immune link, cytokine regulation and carbohydrate metabolism in patients with alcohol-related and drug-induced chronic diffuse liver diseases. Materials and methods. There were 50 patients with chronic diffuse liver diseases under the supervision: 27 patients with alcoholic liver disease — 16 (59.3 %) men and 11 (40.7 %) women with the average age of (37.6 ± 2.4) years; and 23 individuals with toxic drug-induced hepatitis — 6 (26.1 %) men and 17 (73.9 %) women aged (49.2 ± 3.1) years. All patients underwent biochemical and immunological blood tests. The levels of interleukin 6 (IL-6), IL-10, tumor necrosis factor α (TNF-α), and the HOMA-IR were also determined. Results. Most patients with alcoholic liver disease and toxic drug-induced hepatitis are characterized by the presence of cytolytic and cholestatic syndromes, mainly of a minimal degree of activity. Signs of hypercoagulation were found 2 times more often among patients with alcoholic liver disease than among those with toxic drug-induced hepatitis (χ2 = 4.43; p < 0.05). In drug-induced liver injury, an increase in the level of prothrombin index was observed 6.5 times more often (χ2 = 10.87; p < 0.01). A significant 1.8-fold decrease in the number of T-killers (p < 0.05) was found in patients with drug-induced liver injury compared to the control group, while in patients with alcoholic liver disease, the activation of the humoral immunity was determined. There was a significant increase in IL-6, TNF-α, the ratio of pro-inflammatory and anti-inflammatory cytokines, the development of insulin resistance in persons with alcohol-related liver damage, while a significant decrease in IL-10 was typical for patients with toxic drug-induced hepatitis. Conclusions. The analysis of the features of the functional state of the liver, immune link, cytokine regulation and carbohydrate metabolism in the examined patients revealed indicators that can be considered laboratory markers for the development and progression of toxic liver lesions.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.
Sayiner M, Koenig A, Henry L, Younossi ZM. Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World. Clin Liver Dis. 2016;20(2):205-214. doi:10.1016/j.cld.2015.10.001.
Goldberg D, Ditah IC, Saeian K, et al. Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation. Gastroenterology. 2017;152(5):1090-1099.e1. doi:10.1053/j.gastro.2017.01.003.
Marroni CA, Fleck AM Jr, Fernandes SA, et al. Liver transplantation and alcoholic liver disease: History, controversies, and considerations. World J Gastroenterol. 2018;24(26):2785-2805. doi:10.3748/wjg.v24.i26.2785.
Fleming MF, Anton RF, Spies CD. A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels. Alcohol Clin Exp Res. 2004;28(9):1347-1355. doi:10.1097/01.alc.0000139815.89794.be.
Ivashkin VT, Baranovsky AYu, Raikhelson KL, et al. Drug-induced liver injuries (clinical guidelines for physicians). Rossijskij žurnal gastroènterologii, gepatologii, koloproktologii. 2019;29(1):85-115. doi:10.22416/1382-4376-2019-29-1-101-131. (in Russian).
Caballería L, Pera G, Arteaga I, et al. High Prevalence of Liver Fibrosis Among European Adults With Unknown Liver Disease: A Population-Based Study. Clin Gastroenterol Hepatol. 2018;16(7):1138-1145.e5. doi:10.1016/j.cgh.2017.12.048.
Sumerkina VA, Telesheva LF, Golovneva ES, Kvyatkovskaya SV, Dvorchik EE. Lymphocyte subpopulation profile in young men with metabolic syndrome. Meditsinskaya Immunologiya. 2016;18(2):187-191. doi:10.15789/1563-0625-2016-2-187-192. (in Russian).
Tatarchuk OM, Didenko VI, Melanich SL, Kudryavtseva VYe. Immunological reactivity in patients with chronic diffuse liver diseases. Gastroenterologìa. 2018;52(4):222-226. doi:10.22141/2308-2097.52.4.2018.154142. (in Ukrainian).