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Background. Today, the development and implementation of non-invasive methods for the diagnosis of ulcerative colitis is certainly an actual task of the scientific community, the solution of which will allow us to prescribe the adequate treatment in time and to improve the quality of life of patients. Given that the differences between women and men in the parameters determining the state of health are generally recognized, the purpose of the work was to determine the gender characteristics of the level of biological markers of intestinal inflammation in patients with ulcerative colitis. Materials and methods. Sixty patients with ulcerative colitis were examined, among them there were 31 (51.7 %) men and 29 (48.3 %) women with mean age of (40.28 ± 1.34) years. The comparison group consisted of 20 patients with irritable bowel syndrome. By means of enzyme immunoassay using a StatFax 303 Plus analyzer (USA) with Immundiagnostik (Germany) test kit, we determined the level of fecal myeloperoxidase, the content of α1-antitrypsin in the blood serum and feces, and the level of fecal calprotectin using a Bühlmann test kit (Switzerland). Results. Fecal myeloperoxidase and calprotectin are specific markers of intestinal inflammation, which is confirmed by established correlations between the endoscopic activity of intestinal inflammation and its content: r = 0.632; p < 0.05, and r = 0.532; p < 0.05, respectively. The concentration of α1-antitrypsin in the feces of men is 3 times higher than that in women (p < 0.05), and, on the contrary, the level of α1-antitrypsin in the blood is higher in female patients compared to men (p < 0.05). The discovered correlation between the content of α1-antitrypsin in the feces and the male gender (r = 0.528; p < 0.05) indicates a higher activity of the inflammatory process in the colon in men. Conclusions. Gender differences in the level of non-invasive markers of activity of ulcerative colitis should be taken into account when assessing the clinical signs of patients and monitoring the effectiveness of their treatment.
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Stepanov YuM, Skyrda IYu, Petishko OP. Chronic inflammatory bowel disease: epidemiological features in Ukraine. Gastroenterologìa. 2017;51(2):97-105. doi: 10.22141/2308-2097.51.2.2017.101703. (in Ukrainian).
Yamamoto-Furusho JK, Sarmiento-Aguilar A, Toledo-Mauriño JJ, et al. Incidence and prevalence of inflammatory bowel disease in Mexico from a nationwide cohort study in a period of 15 years (2000-2017). Medicine (Baltimore). 2019 Jul;98(27):e16291. doi: 10.1097/MD.0000000000016291.
Ng SC, Shi HY, Hamidi N, et al. The worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Gastroenterology. 2017;152(5):S970-1. doi: 10.1016/S0016-5085(17)33292-4.
Shah SC, Khalili H, Gower-Rousseau C, et al. Sex-based differences in incidence of inflammatory bowel diseases-pooled analysis of population-based studies from Western countries. Gastroenterology. 2018 Oct;155(4):1079-1089.e3. doi: 10.1053/j.gastro.2018.06.043.
Dorofeyev AE, Vdovichenko VI, Nahurna YaV, Khaldi H, Dorofeyeva AA. Comparative prevalence and features of the course of ulcerative colitis in countries of the same geographical meridian: Ukraine-Tunisia. Testing the North-South hypothesis. Gastroenterologìa. 2019;53(1):34-8. doi: 10.22141/2308-2097.53.1.2019.163455. (in Russian).
Ventham NT, Kennedy NA, Nimmo ER, Satsangi J. Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics. Gastroenterology. 2013 Aug;145(2):293-308. doi: 10.1053/j.gastro.2013.05.050.
Pabby V, Oza SS, Dodge LE, et al. In vitro fertilization is successful in women with ulcerative colitis and ileal pouch anal anastomosis. Am J Gastroenterol. 2015 Jun;110(6):792-7. doi: 10.1038/ajg.2014.400.
Pershko AM, Grinevich VB, Solovyov IA, Shotik AV, Kurilo DP. Private the pathogenesis of inflammatory bowel diseases. Eksperimental'naia i klinicheskaia gastroenterologiia. 2018;(153):140-149. (in Russian).
Kerezman AO. Gender features of morbidity and prevalence illnesses of organs digestion among the adult population in Transcarpathia region. Ukraine. Nation’s Health. 2015;(33):136-143. (in Ukrainian).
Sceats LA, Morris AM, Bundorf MK, Park KT, Kin C. Sex differences in treatment strategies among patients with ulcerative colitis: a retrospective cohort analysis of privately insured patients. Dis Colon Rectum. 2019 May;62(5):586-594. doi: 10.1097/DCR.0000000000001342.
Matiukhin AA. Diagnosticheskaia i prognosticheskaia tsennost' markerov aktivnosti vospalitel'nogo protsessa u bol'nykh s zabolevaniiami zheludochno-kishechnogo trakta. Diss. kand. med. nauk [Diagnostic and prognostic value of inflammatory activity markers in patients with diseases of the gastrointestinal tract. PhD diss.]. Voronezh; 2017. 136 p. (in Russian).
Nikitin AV, Vasilyeva LV, Matiukhin AA. Non-invasive markers of inflammatory bowel disease activity. Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2016;26(6):106-111. (in Russian).
Vinnyk NV, Tatarchuk OM, Stoikevych MV, Kudriavtseva VYe, Sorochan OV. Features of colon microbiocenosis and fecal calprotectin level in patients with chronic inflammatory bowel disease depending on nutritional status. Gastroenterologìa. 2016;(60):21-25. doi: 10.22141/2308-2097.2.60.2016.74724. (in Ukrainian).