Quantitative analysis of the rate of the antisecretory effect of combined proton pump inhibitor Ezolong
Background. The treatment of acid-related diseases is an urgent problem of modern gastroenterology and is due to the wide spread of this group of nosologies in the structure of gastrointestinal pathology. Proton pump inhibitors play the leading role in the treatment of these diseases. The criteria for their choice is the time of onset of action, severity and duration of acid suppression, the stability of the effect during the day, the presence of different dosages of the drug. That is why, in recent years, preference is given to combined drugs. Now in Ukraine, a newer generation of combined drugs is used, one of them is Ezolong. This drug, which, in addition to high-quality esomeprazole (at a dosage of 20 or 40 mg), contains another active ingredient — an antacid in the form of sodium hydrocarbonate (1080 mg). It is this combination that makes this drug unique. The purpose of the study was to determine the speed of the effect of the combined drug Ezolong (esomeprazole 40 mg + sodium hydrocarbonate 1080 mg) on the state of gastric acid production and degree of its inhibition when using a single dose of the drug. Materials and methods. Twenty patients with various forms of chronic gastroduodenitis were taken under observation. The level of acid production was assessed using intragastric pH monitoring with AG-1 acidograph. Next, patients received a single dose of Ezolong (40 mg) and were under observation for 3 hours. Results. Analyzing the rate of antisecretory effect of a single dose of Ezolong, we found that in 95 % of patients this drug leads to an increase in intragastric pH to hypoacidic numbers (from 3.0 to 7.8), in some patients even anacidic pH values are observed. It is proved that Ezolong is characterized by a rapid onset of action (on average 6 minutes) and a significant increase in pH to severe hypoacidity. Conclusions. Ezolong administration provides active, powerful and long-lasting suppression of gastric acid production, it is effective and safe for the treatment of acid-related diseases.
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