DOI: https://doi.org/10.22141/2308-2097.53.1.2019.163456

Age-related and gender features of circulating immune complexes and lipid metabolism in inflammatory bowel diseases

M.V. Stoikevych, I.A. Klenina, O.M. Tatarchuk, V.A. Karachinova, N.S. Fedorova

Abstract


Background. The purpose of the present work was to assess the level of circulating immune comple­xes (CIC) and lipid metabolism state in patients with inflammatory bowel disease (IBD). Materials and methods. We examined 80 patients with IBD: 53 with ulcerative colitis (UC) and 27 with Crohn’s disease (CD). Depending on the gender, they were divided into two groups: 40 womеn and 40 men. Also, depending on the age, all patients were divided into three groups: young (45 individuals — 28 with UC and 17 with CD); middle-aged (15 persons — 10 with UC and 5 with CD); elderly (20 patients — 15 with UC and 5 with CD). The control group included 20 appa­rently healthy individuals. In patients’ blood serum, the levels of CIC, total cholesterol, triglycerides, phospholipids, high-density, low-density and very low-density lipoprotein cholesterol were determined, as well as atherogenic index. Results. Serum level of CIC significantly exceeded the normal values in women with IBD — by 1.57 times (p < 0.05), which can be considered as an indicator of inflammation intensity, involvement of the immune system in the pathological process. In women with UC, the content of CIC was significantly increased — by 1.62 times (p < 0.05) compared to the control group. In IBD, the level of CIC depended on the age of patients; it was significantly increased — by 1.5 times (p < 0.05) and 1.4 times (p < 0.05) — in middle-aged patients and in the elderly, respectively, compared to a group of young patients. The correlation between the level of CIC and the age (r = +0.552; p = 0.025) was established. The violation of lipid metabolism was observed in women with UC, which manifested in 1.7-time reduction of serum triglycerides (p < 0.001); in men with CD, a decrease in this indicator by 1.5 times (p < 0.05) occurred compared to the control group. In women with UC, the serum level of very low-density lipoproteins was 2 times lower (p < 0.05), and in men with CD — 1.8 times (p < 0.05) as compared to controls. A probable reduction in the content of triglycerides was detected: by 1.5 times (p < 0.05) and 1.6 times (p < 0.05) in young patients with UC and CD, respectively, and by 1.6 times (p < 0.05) in middle-aged patients with CD. In parallel, there was a pronounced tendency to cholesterol lowering in all young patients with IBD. A probable decrease in the atherogenic index was detected in young patients. Conclusions. The completed studies allowed establishing and confirming the presence of biochemical changes in patients with IBD (lipid metabolism and the content of CIC), which play the main role in the pathogenetic mechanisms of these diseases.


Keywords


inflammatory bowel diseases; ulcerative colitis; Crohn’s disease; circulating immune complexes; lipid metabolism

Full Text:

PDF

References


Boiko TI, Stoikevich MV, Kolbasina EV, Sorochan EV. The state of the function of the vascular endothelium in patients with chronic inflammatory diseases. Modern Gastroenterology. 2010;(51):5-10. (in Russian).

Stepanov YuM, Skyrda IYu, Petishko OP. Chronic inflammatory bowel diseases: epidemiological features in Ukraine. Gastroenterologia. 2017;51(2):11-19. doi: 10.22141/2308-2097.51.2.2017.101703. (in Ukrainian).

Nosova ІА. Difficulties in diagnosing and substantiating the principles of basic treatment of patients with non-specific inflammatory bowel diseases. Modern Gastroenterology. 2007;(36):51-55. (in Ukrainian).

Pasijeshvili LM, Andrusha AB. Chronic colitis as a factor in the development and progression of secondary osteoporosis in patients with spinal osteochondrosis. Modern Gastroenterology. 2008;(40):30-33. (in Ukrainian).

Vdovychenko VI, Kornijchuk OP, Merencova OO, Losynsky JuS. Comparative characteristics of intestinal microbiocenosis in patients with irritable bowel syndrome and ulcerative colitis. Modern Gastroenterology. 2010;(54):67-70. (in Ukrainian).

Tatianina OF, Potapov AS, Namazova LS, Tsimbalova YeG, Kucherenko AG, Surkov AN. Markers of the enteric inflammation in the event of intestinal diseases: literature review. Pediatricheskaya Farmakologiya. 2008;5(3):39-45. (in Russian).

Stepanov YuM, Fedorova NS. Fecal calprotectin content in patients with chronic inflammatory bowel disease. 2010;(52):44-48. (in Russian).

Dorofjejev АЕ, Dragomyryc'ka NV, Izhа GM, Rossohina OO. Affection of hepatobilialry system in ulcerative colitis and Crohn’s diseas. University clinic. 2013;9(2):228-230. (in Ukrainian).

Kalinkina NV. Osobennosti metabolizma oksida azota pod vliianiem razlichnykh kumuliativnykh doz antratsiklinovykh preparatov. Diss. kand. med. nauk [Features of the metabolism of nitric oxide under the influence of various cumulative doses of anthracycline drugs. PhD diss.]. Donetsk; 2010. 6 p. (in Russian).




Copyright (c) 2019 GASTROENTEROLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2019

 

   Seo анализ сайта