DOI: https://doi.org/10.22141/2308-2097.53.1.2019.163455

Comparative prevalence and features of the course of ulcerative colitis in countries of the same geographical meridian: Ukraine-Tunisia. Testing the North-South hypothesis

A.E. Dorofeyev, V.I. Vdovichenko, Ya.V. Nahurna, Khaldi Hatem, A.A. Dorofeyeva

Abstract


Background. Chronic inflammatory bowel diseases (ulcerative colitis (UC) and Crohn’s disease) are severe, incu­rable illnesses accompanied by loss of work ability and early death due to their complications in most cases. The real prevalence of these diseases remains poorly understood because of statistical reporting built on patients’ access to medical care. The purpose of the work was to carry out a comparative analysis of the prevalence and features of UC course in Ukraine and Tunisia located on the same geographic meridian at a distance of 1,626 km. Results. When comparing the features of UC course in the inhabitants of two countries — Ukraine and Tunisia located on the same geographical meridian at a distance of more than 1,600 km, the gradient factor within the European continent can be traced. This is manifested in the fact that UC is more often affect the younger population of Tunisia (the average age is 37 years, compared to 45 years for Ukrainians); in addition, among Tunisians patients with UC, there are 1.5 times more men than women. There is the predominance of pancolitis and severe course of the disease in Ukrainian patients with UC. Conclusions. Thus, when analyzing the population of UC patients in Ukraine and Tunisia, the incidence of UC in the Ukrainian population appeared to be increased. Ulcerative colitis in Ukrainian patients has more common forms and severe course than in patients from Tunisia. This is due to the peculiarities of environmental factors, genetic predisposition, changes in immunity and intestinal microbiome and confirms the North-South hypothesis.


Keywords


ulcerative colitis; prevalence; course; Ukraine; Tunisia

References


Rudenko NN, Dorofeev AE, Agibalov AN. Forlax in the treatment of chronic constipation of various origins. Likars'ka sprava. 2000;(3-4):94-96. (in Russian).

Rudenko NN, Tomash OV, Dorofeev AE. Treatment of chronic constipation: from theory to practice. Novosti Meditsiny i Farmatsii. Gastroenterologiia. 2013;(457):37-39. (in Russian).

Camilleri M, Ford AC, Mawe GM, et al. Chronic constipation. Nat Rev Dis Primers. 2017 Dec 14;3:17095. doi: 10.1038/nrdp.2017.95.

Chassagne P, Ducrotte P, Garnier P, Mathiex-Fortunet H. Tolerance and Long-Term Efficacy of Polyethylene Glycol 4000 (Forlax®) Compared to Lactulose in Elderly Patients with Chronic Constipation. J Nutr Health Aging. 2017;21(4):429-439. doi: 10.1007/s12603-016-0762-6.

Cinca R, Chera D, Gruss HJ, Halphen M. Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation - a comparison in a controlled environment. Aliment Pharmacol Ther. 2013 May;37(9):876-86. doi: 10.1111/apt.12278.

Enck P, Leinert J, Smid M, Köhler T, Schwille-Kiuntke J. Functional Constipation and Constipation-Predominant Irritable Bowel Syndrome in the General Population: Data from the GECCO Study. Gastroenterol Res Pract. 2016;2016:3186016. doi: 10.1155/2016/3186016.

Enck P, Leinert J, Smid M, Köhler T, Schwille-Kiuntke J. Prevalence of constipation in the German population - a representative survey (GECCO). United European Gastroenterol J. 2016 Jun;4(3):429-37. doi: 10.1177/2050640615603009.

Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG. Osmotic and stimulant laxatives for the management of childhood constipation. Cochrane Database Syst Rev. 2016 Aug 17;(8):CD009118. doi: 10.1002/14651858.CD009118.pub3.

Hyams JS, Di Lorenzo C, Saps M, Shulman RJ, Staiano A, van Tilburg M. Functional disorders: Children and Adolescents. Gastroenterology. 2016 Feb 15. pii: S0016-5085(16)00181-5. doi: 10.1053/j.gastro.2016.02.015.

Koppen IJN, Vriesman MH, Saps M, et al. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Jul;198:121-130.e6. doi: 10.1016/j.jpeds.2018.02.029.

Mearin F, Lacy BE, Chang L, et al. Bowel Disorders. Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00222-5. doi: 10.1053/j.gastro.2016.02.031.

Llerena E, Varea Calderón V, Pujol Muncunill G, et al. Comparison of the effectiveness and safety of polyethylene glycol with and without electrolytes in the treatment of chronic constipation. An Pediatr (Barc). 2016 Jul;85(1):34-40. doi: 10.1016/j.anpedi.2015.08.009. (in Spanish).

Lyseng-Williamson KA. Macrogol (polyethylene glycol) 4000 without electrolytes in the symptomatic treatment of chronic constipation: a profile of its use. Drugs Ther Perspect. 2018;34(7):300-310. doi: 10.1007/s40267-018-0532-0.

Mearin F, Ciriza C, Mínguez M, et al. Irritable bowel syndrome with constipation and functional constipation in adults: Treatment (Part 2 of 2). Semergen. 2017 Mar;43(2):123-140. doi: 10.1016/j.semerg.2017.01.001. (in Spanish).

Mínguez M, López Higueras A, Júdez J. Use of polyethylene glycol in functional constipation and fecal impaction. Rev Esp Enferm Dig. 2016 Dec;108(12):790-806. doi: 10.17235/reed.2016.4571/2016.

Prasad VG, Abraham P. Management of chronic constipation in patients with diabetes mellitus. Indian J Gastroenterol. 2017 Jan;36(1):11-22. doi: 10.1007/s12664-016-0724-2.

Quigley EMM, Horn J, Kissous-Hunt M, Crozier RA, Harris LA. Better Understanding and Recognition of the Disconnects, Experiences, and Needs of Patients with Irritable Bowel Syndrome with Constipation (BURDEN IBS-C) Study: Results of an Online Questionnaire. Adv Ther. 2018 Jul;35(7):967-980. doi: 10.1007/s12325-018-0733-x.

Sumida K, Molnar MZ, Potukuchi PK, et al. Constipation and risk of death and cardiovascular events. Atherosclerosis. 2019 Feb;281:114-120. doi: 10.1016/j.atherosclerosis.2018.12.021.

Vitton V, Damon H, Benezech A, et al. Clinical practice guidelines from the French National Society of Coloproctology in treating chronic constipation. Eur J Gastroenterol Hepatol. 2018 Apr;30(4):357-363. doi: 10.1097/MEG.0000000000001080.

Wali RK, Bianchi L, Kupfer S, et al. Prevention of colonic neoplasia with polyethylene glycol: A short term randomized placebo-controlled double-blinded trial. PLoS One. 2018 Apr 4;13(4):e0193544. doi: 10.1371/journal.pone.0193544.

Yachha SK, Srivastava A, Mohan N, et al. Management of Childhood Functional Constipation: Consensus Practice Guidelines of Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition and Pediatric Gastroenterology Chapter of Indian Academy of Pediatrics. Indian Pediatr. 2018 Oct 15;55(10):885-892.




Copyright (c) 2019 GASTROENTEROLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2019

 

   Seo анализ сайта