Celiac disease: modern view on the diagnosis and treatment

Yu.M. Stepanov, А.V. Salenko


The article presents an analysis of the etiopathogenetic mechanisms of celiac disease. The modern methods of diagnosing this pathology are described, the algorithm of their use is analyzed. The management of patients with celiac disease is considered.


celiac disease; diagnosis; treatment


Bai JC, Fried M, Corazza GR, et al. World Gastroenterology Organisation global guidelines on celiac disease. J Clin Gastroenterol. 2013 Feb;47(2):121-6. doi: 10.1097/MCG.0b013e31827a6f83.

Koning F. Celiac Disease: Across the Threshold of Tolerance. In: Fasano A, Troncone R, Branski D, editors. Frontiers in Celiac Disease. Basel: Karger; 2008. 82-88 pp. doi:10.1159/000128662.

Mariné M, Farre C, Alsina M, et al. The prevalence of coeliac disease is significantly higher in children compared with adults. Aliment Pharmacol Ther. 2011 Feb;33(4):477-86. doi: 10.1111/j.1365-2036.2010.04543.x.

Bel'mer SV, Revnova MO, editors. Tseliakiia u detei [Celiac disease in children]. Moscow: Medpraktika-M; 2013. 416 p. (in Russian).

Frost AR, Band MM, Conway GS. Serological screening for coeliac disease in adults with Turner’s syndrome: prevalence and clinical significance of endomysium antibody positivity. Eur J Endocrinol. 2009 Apr;160(4):675-9. doi: 10.1530/EJE-08-0846.

Parfenov AI. Enterologiia [Enterology]. Moscow: Triada-X; 2002. 380-420 pp. (in Russian).

Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 2001 Feb;120(3):636-51.

Makharia GK, Baba CS, Khadgawat R, et al. Celiac disease: variations of presentations in adults. Indian J Gastroenterol. 2007 Jul-Aug;26(4):162-6.

Lorenz RG. Celiac disease. Clinical Laboratory News. 2007;(33):10-15.

Admou B, Essaadouni L, Krati K, et al. Atypical celiac disease: from recognizing to managing. Gastroenterol Res Pract. 2012;2012:637187. doi: 10.1155/2012/637187.

Fasano A. Clinical presentation of celiac disease in the pediatric population. Gastroenterology. 2005 Apr;128(4 Suppl 1):S68-73.

Kondrat'eva EI, Yankina GN. Celiac disease in children. Controversial issues of diagnosing and treatment. Pediatric Nutrition. 2010;8(2):37-41. (in Russian).

Parfenov AI. Tseliakiia. Evoliutsiia predstavlenii o rasprostranennosti, klinicheskikh proiavleniiakh i znachimosti etiotropnoi terapii [Celiac disease. The evolution of ideas about the prevalence, clinical manifestations and significance of etiotropic therapy]. Moscow: Anakharsis; 2007. 376 p. (in Russian).

Lazareva TA. Celiac disease in children and adolescents. Voprosy sovremennoi pediatrii. 2008;7(4):80-84. (in Russian).

Rostami Nejad M, Hogg-Kollars S, Ishaq S, Rostami K. Subclinical celiac disease and gluten sensitivity. Gastroenterol Hepatol Bed Bench. 2011 Summer;4(3):102-8.

Volta U, Caio G, Stanghellini V, De Giorgio R. The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center. BMC Gastroenterol. 2014 Nov 18;14:194. doi: 10.1186/s12876-014-0194-x.

Radlović N. Celiac Disease. Srp Arh Celok Lek. 2013 Jan-Feb;141(1-2):122-6.

Green PH, Rostami K, Marsh MN. Diagnosis of celiac disease. Best Pract Res Clin Gastroenterol. 2005 Jun;19(3):389-400. doi: 10.1016/j.bpg.2005.02.006.

Cammarota G, Cesaro P, Martino A, et al. High accuracy and cost-effectiveness of a biopsy-avoiding endoscopic approach in diagnosing coeliac disease. Aliment Pharmacol Ther. 2006 Jan 1;23(1):61-9. doi: 10.1111/j.1365-2036.2006.02732.x.

Meijer JW, Wahab PJ, Mulder CJ. Small intestinal biopsies in celiac disease: duodenal or jejunal? Virchows Arch. 2003 Feb;442(2):124-8. doi: 10.1007/s00428-002-0709-7.

Dickey W. Endoscopic markers for celiac disease. Nat Clin Pract Gastroenterol Hepatol. 2006 Oct;3(10):546-51. doi: 10.1038/ncpgasthep0601.

Korponay-Szabó IR, Raivio T, Laurila K, et al. Coeliac disease case finding and diet monitoring by point-of-care testing. Aliment Pharmacol Ther. 2005 Oct 15;22(8):729-37. doi: 10.1111/j.1365-2036.2005.02663.x.

Nemec G, Ventura A, Stefano M, et al. Looking for celiac disease: diagnostic accuracy of two rapid commercial assays. Am J Gastroenterol. 2006 Jul;101(7):1597-600. doi: 10.1111/j.1572-0241.2006.00597.x.

Korponay-Szabó IR, Szabados K, Pusztai J, et al. Population screening for coeliac disease in primary care by district nurses using a rapid antibody test: diagnostic accuracy and feasibility study. BMJ. 2007 Dec 15;335(7632):1244-7. doi: 10.1136/bmj.39405.472975.80.

Bienvenu F, Besson Duvanel C, Seignovert C, Rouzaire P, Lachaux A, Bienvenu J. Evaluation of a point-of-care test based on deamidated gliadin peptides for celiac disease screening in a large pediatric population. Eur J Gastroenterol Hepatol. 2012 Dec;24(12):1418-23. doi: 10.1097/MEG.0b013e3283582d95.

Bienvenu F, Anghel SI, Besson Duvanel C, et al. Early diagnosis of celiac disease in IgA deficient children: contribution of a point-of-care test. BMC Gastroenterol. 2014 Nov 6;14:186. doi: 10.1186/1471-230X-14-186.

DeGaetani M, Tennyson CA, Lebwohl B, et al. Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma. Am J Gastroenterol. 2013 May;108(5):647-53. doi: 10.1038/ajg.2013.45.

Granito A, Muratori P, Cassani F, et al. Anti-actin IgA antibodies in severe coeliac disease. Clin Exp Immunol. 2004 Aug;137(2):386-92. doi: 10.1111/j.1365-2249.2004.02541.x.

Galipeau HJ, Wiepjes M, Motta JP, et al. Novel role of the serine protease inhibitor elafin in gluten-related disorders. Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48.

Burns SD. Can Elafin help with gluten intolerance and celiac disease? Available from: Accessed: April 23, 2014.

Catassi C, Fasano A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med. 2010 Aug;123(8):691-3. doi: 10.1016/j.amjmed.2010.02.019.

Copyright (c) 2019 GASTROENTEROLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта