DOI: https://doi.org/10.22141/2308-2097.52.3.2018.141845

Modern approaches to the treatment of irritable bowel syndrome through the prism of the “intestine — brain” axis

Ye.S. Sirchak

Abstract


Irritable bowel syndrome is one of the most common functional disorders of the gastrointestinal tract. Significant role in its occurrence is played by the interaction between the factors of the environment and the individual characteristics of the patient. Among the latter, there are disorders of intestinal motility, visceral hypersensitivity, decreased activity of the immune system, violation of the intestinal barrier function, low-grade inflammation and changes in intestinal microbiota due to disorders in the functioning of signaling system between the intestines and the brain. The article presents modern information on the influence of intestinal microbiota on the brain functioning through the axis, which includes the central nervous system, the vagus nerve, the exchange of tryptophan, neuroendocrine and neuroimmune systems, the hypothalamic-pituitary-adrenal, autonomic nervous and enteric nervous system. The expediency and effectiveness of using Alflorex (В.infantis 35624 strain) to promote the reduction of all clinical symptoms of the irritable bowel syndrome due to its immunomodulatory, anti-inflammatory effects, as well as the effect on the exchange of tryptophan and sero­tonin, which, in turn, modulates motor activity and visceral hypersensitivity through the normalization of signaling between the intestines and the brain.

Keywords


irritable bowel syndrome; “intestine — brain” axis; intestinal microbiota; В.infantis 35624

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