Role of visceral hypersensitivity in the development of irritable bowel syndrome

Main Article Content

Yu.M. Stepanov
I.Ya. Budzak


The article presents the aspects of pathogenesis of irritable bowel syndrome. One of the crucial pathogenetic factors — visceral hypersensitivity was considered in detail. There were shown the historical aspects of studying, forms and ways for evaluating visceral hypersensitivity. The correlation between visceral hypersensitivity and other factors of irritable bowel syndrome pathogenesis was analyzed.

Article Details

How to Cite
Stepanov, Y., & Budzak, I. (2018). Role of visceral hypersensitivity in the development of irritable bowel syndrome. GASTROENTEROLOGY, 52(2), 104–108.
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Farzaei MH, Bahramsoltani R, Abdollahi M, Rahimi R. The role of visceral hypersensitivity in irritable bowel syndrome: pharmacological targets and novel treatments. J Neurogastroenterol Motil. 2016 Oct 30;22(4):558-574. doi: 10.5056/jnm16001.

Bouin M, Meunier P, Riberdy-Poitras M, Poitras P. Pain hypersensitivity in patients with functional gastrointestinal disorders: a gastrointestinal-specific defect or a general systemic condition? Dig Dis Sci. 2001 Nov;46(11):2542-8. doi: 10.1023/A:1012356827026.

Mujagic Z, Jonkers DMAE, Ludidi S, et al. Biomarkers for visceral hypersensitivity in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13137.

Kanazawa M, Hongo M, Fukudo S. Visceral hypersensitivity in irritable bowel syndrome J Gastroenterol Hepatol. 2011 Apr;26 Suppl 3:119-21. doi: 10.1111/j.1440-1746.2011.06640.x.

Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut. 1973 Feb;14(2):125-32.

Barbara G, Wang B, Stanghellini V, et al. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology. 2007 Jan;132(1):26-37. doi: 10.1053/j.gastro.2006.11.039.

Klooker TK, Braak B, Koopman KE, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59(9):1213-21. doi: 10.1136/gut.2010.213108.

Stasi C, Bellini M, Bassotti G, Blandizzi C, Milani S. Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome. Tech Coloproctol. 2014 Jul;18(7):613-21. doi: 10.1007/s10151-013-1106-8.

Rolland-Fourcade C, Denadai-Souza A, Cirillo C, et al. Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Gut. 2017 Oct;66(10):1767-1778. doi: 10.1136/gutjnl-2016-312094.

Lobo B, Vicario M, Martinez C, et al. Clinical improvement in IBS after disodium cromoglycate involves mast cell-mediated toll-like receptor signaling downregulation. Gastroenterology. 2011 May;140(5, Suppl 1):S499-S500. doi: 10.1016/S0016-5085(11)62067-2.

Nozu T, Miyagishi S, Kumei S, Nozu R, Takakusaki K, Okumura T. Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats. Eur J Pharmacol. 2018 Jan 5;818:228-234. doi: 10.1016/j.ejphar.2017.10.056.

Yue H, Bin L, Chaoying C, Meng Z, Meng L, Xi W. Potential Regulatory Effects of Corticotropin-Releasing Factor on Tight Junction-Related Intestinal Epithelial Permeability are Partially Mediated by CK8 Upregulation. Cell Physiol Biochem. 2017;44(3):1161-1173. doi: 10.1159/000485420.

Strege PR, Mazzone A, Bernard CE et al. Irritable bowel syndrome (IBS) patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity. Am J Physiol Gastrointest Liver Physiol. 2018 Apr 1;314(4):G494-G503. doi: 10.1152/ajpgi.00016.2017.

Zhou SY, Gillilland M 3rd, Wu X, et al. FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction. J Clin Invest. 2018 Jan 2;128(1):267-280. doi: 10.1172/JCI92390.

Theodorou V, Belgnaoui AA, Agostini S, Eutamene H. Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome. Gut Microbes. 2014 May-Jun;5(3):430-6. doi: 10.4161/gmic.29796.

Nébot-Vivinus M, Harkat C, Bzioueche H, et al. Multispecies probiotic protects gut barrier function in experimental models. World J Gastroenterol. 2014 Jun 14;20(22):6832-43. doi: 10.3748/wjg.v20.i22.6832.

Pérez-Berezo T, Pujo J, Martin P, et al. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat Commun. 2017 Nov 3;8(1):1314. doi: 10.1038/s41467-017-01403-9.

Botschuijver S, Roeselers G, Levin E, et al. Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats. Gastroenterology. 2017 Oct;153(4):1026-1039. doi: 10.1053/j.gastro.2017.06.004.

Jin Y, Ren X, Li G, et al. Beneficial effects of Rifaximin in post-infectious irritable bowel syndrome mouse model beyond gut microbiota. J Gastroenterol Hepatol. 2018 Feb;33(2):443-452. doi: 10.1111/jgh.13841.

Crouzet L, Gaultier E, Del'Homme C, et al. The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota. Neurogastroenterol Motil. 2013 Apr;25(4):e272-82. doi: 10.1111/nmo.12103.

Moayyedi P, Ford AC, Talley NJ, et al. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut. 2010 Mar;59(3):325-32. doi: 10.1136/gut.2008.167270.

Ludidi S, Mujagic Z, Jonkers D, et al. Markers for visceral hypersensitivity in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2014 Aug;26(8):1104-11. doi: 10.1111/nmo.12365.

Ludidi S, Conchillo JM, Keszthelyi D, et al. Rectal hypersensitivity as hallmark for irritable bowel syndrome: defining the optimal cutoff. Neurogastroenterol Motil. 2012 Aug;24(8):729-33, e345-6. doi: 10.1111/j.1365-2982.2012.01926.x.

Vergnolle N. Modulation of visceral pain and inflammation by protease-activated receptors. Br J Pharmacol. 2004 Apr;141(8):1264-74. doi: 10.1038/sj.bjp.0705750.

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