Idiopathic non-cirrhotic portal hypertension and its causes

O.M. Vlasova


Idiopathic non-cirrhotic portal hypertension is poorly diagnosed disease of unclear etiology. The disease is slowly progressive and benign, its outcome is more optimistic than in the treatment of portal hypertension complications. This disease is diagnosed in different countries of the world and in different ethnic groups with various risk factors that explains the existence of various terminologies and the absence of standardized diagnostic criteria. But to diagnose idiopatic non-cirrhotic portal hypertension, other pathology should be excluded clinically and histologically.


idiopathic non-cirrhotic portal hypertension


Khukhlina O.S. Portal acute hypertension. Hostri ta nevidkladni stany u praktytsi likaria. 2008;(Suppl 1):27-31.

Amitrano L, Guardascione MA, Manguso F, et al. The effectiveness of current acute variceal bleed treatments in unselected cirrhotic patients: refining short. Am J Gastroenterol. 2012 Dec;107(12):1872-8. doi: 10.1038/ajg.2012.313.

Asrani SK, Talwalkar JA, Kamath PS, et al. Role of magnetic resonance elastography in compensated and decompensated liver disease. J Hepatol. 2014 May;60(5):934-9. doi: 10.1016/j.jhep.2013.12.016.

Bosch J, Groszmann RJ, Shah VH. Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments. J Hepatol. 2015 Apr;62(1 Suppl):S121-30. doi: 10.1016/j.jhep.2015.01.003.

D’Amico G, Pasta L, Morabito A, et al. Competing risks and prognostic stages of cirrhosis: a 25-year inception cohort study of 494 patients. Aliment Pharmacol Ther. 2014 May;39(10):1180-93. doi: 10.1111/apt.12721.

Ding NS, Nguyen T, Iser DM, et al. Liver stiffness plus platelet count can be used to exclude high-risk oesophageal varices. Liver Int. 2016 Feb;36(2):240-5. doi: 10.1111/liv.12916.

Elkrief L, Rautou PE, Ronot M, et al. Prospective comparison of spleen and liver stiffness by using shear-wave and transient elastography for detection of portal hypertension in cirrhosis. Radiology. 2015 May;275(2):589-98. doi: 10.1148/radiol.14141210.

Fortune B, Garcia-Tsao G, Ciarleglio M, et al. Vapreotide Study Group. Child-Turcotte-Pugh Class is best at stratifying risk in variceal hemorrhage: analysis of a U.S. multi-center prospective study. J Clin Gastroenterol. 2017;51(5):446-453. doi: 10.1097/MCG.0000000000000733.

de Franchis R; Baveno VI Faculty. Expanding consensus in portal hypertension. Report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015 Sep;63(3):743-52. doi: 10.1016/j.jhep.2015.05.022.

Garcia-Tsao G. Natural history of cirrhosis. In: Cardenas A, Keaveny A, eds. Complications of Cirrhosis. Springer, Cham; 2015. 13-20 рр.

Peredery VG, Tkach SM. Practical gastroenterology. Vinnitsa; 2011. 769 p.

Goel A, Alagammai PL, Nair S. ADAMTS13 deficiency, despite well-compensated liver functions in patients with noncirrhotic portal hypertension. Indian J Gastroenterol. 2014 Jul;33(4):355-63. doi: 10.1007/s12664-014-0460-4.

Khanna R, Sarin S. Non-cirrhotic portal hypertension - diagnosis and management. J Hepatol. 2014 Feb;60(2):421-41. doi: 10.1016/j.jhep.2013.08.013.

Procopet B, Berzigotti A, Abraldes JG, et al. Real-time shear-wave elastography: applicability, reliability and accuracy for clinically significant portal hypertension. J Hepatol. 2015 May;62(5):1068-75. doi: 10.1016/j.jhep.2014.12.007.

Reverter E, Tandon P, Augustin S, et al. A MELD-based model to determine risk of mortality among patients with acute variceal bleeding. Gastroenterology. 2014 Feb;146(2):412-19.e3. doi: 10.1053/j.gastro.2013.10.018.

Scaglione S, Kliethermes S, Cao G, et al. The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol. 2015 Sep;49(8):690-6. doi: 10.1097/MCG.0000000000000208.

Sinagra E, Perricone G, D’Amico M, Tine F, D’Amico G. Systematic review with meta-analysis: the haemodynamic effects of carvedilol compared with propranolol for portal hypertension in cirrhosis. Aliment Pharmacol Ther. 2014 Mar;39(6):557-68. doi: 10.1111/apt.12634.

Singh S, Venkatesh SK, Loomba R, et al. Magnetic resonance elastography for staging liver fibrosis in non-alcoholic fatty liver disease: a diagnostic accuracy systematic review and individual participant data pooled analysis. Eur Radiol. 2016 May;26(5):1431-40. doi: 10.1007/s00330-015-3949-z.

Tandon P, Abraldes JG, Keough A, et al. Risk of bacterial infection in patients with cirrhosis and acute variceal hemorrhage, based on Child-Pugh class, and effects of antibiotics. Clin Gastroenterol Hepatol. 2015 Jun;13(6):1189-96.e2. doi: 10.1016/j.cgh.2014.11.019.

Villanueva C, Albillos A, Genesca J, et al. Development of hyperdynamic circulation and response to beta-blockers in compensated cirrhosis with portal hypertension. Hepatology. 2016 Jan;63(1):197-206. doi: 10.1002/hep.28264.

Vispo E, Cevik M, Rockstroh JK, et al. Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients. Clin Infect Dis. 2013 Apr;56(8):1117-22. doi: 10.1093/cid/cit001.

Sherlock S, Dooley J. Disease of the liver and biliary system. 11th ed. Malden, MA: Blackwell Science; 2002. 706 р.

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