Indicators of cytokines in children with hepatobiliary pathology combined with parasitosis

T.V. Sorokman, N.A. Popelyuk, L.V. Shvygar


Background. Hepatobiliary pathology (HBP) in children tend to continual growth, and the pathology itself is characterized by a group of features that are absent in adults. The purpose was to identify the features of the blood serum cytokines in children with HBP and parasitosis. Materials and methods. The main clinical group consisted of 64 children aged 8–18 years with HBP. Comparison group included 25 healthy children matched by age and gender with the main clinical group. Results. Hepatobiliary disorders were prevalent among primary school-aged children. 64.8 % of patients with HBP were diagnosed with helminthiasis or giardiasis. The level of interleukin 4 (IL-4) in children with HBP was almost 11 times higher than that of in the comparison group, tumor necrosis factor α (TNF-α) — 6 times. The highest concentration of IL-4 and TNF-α has been reported in patients with toxocarosis and ascariasis. Conclusions. In the structure of HBP in children, functional disorders of the biliary tract were prevalent. In HBP and concomitant parasitosis (especially ascariasis and toxocarosis), IL-4 and TNF-α levels are significantly higher in patients without concomitant parasitosis.


children; hepatobiliary pathology; interleukin 4; tumor necrosis factor α; parasitosis


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