Indicators of cytokines in children with hepatobiliary pathology combined with parasitosis

T.V. Sorokman, N.A. Popelyuk, L.V. Shvygar

Abstract


Background. Hepatobiliary pathology (HBP) in children tend to continual growth, and the pathology itself is characterized by a group of features that are absent in adults. The purpose was to identify the features of the blood serum cytokines in children with HBP and parasitosis. Materials and methods. The main clinical group consisted of 64 children aged 8–18 years with HBP. Comparison group included 25 healthy children matched by age and gender with the main clinical group. Results. Hepatobiliary disorders were prevalent among primary school-aged children. 64.8 % of patients with HBP were diagnosed with helminthiasis or giardiasis. The level of interleukin 4 (IL-4) in children with HBP was almost 11 times higher than that of in the comparison group, tumor necrosis factor α (TNF-α) — 6 times. The highest concentration of IL-4 and TNF-α has been reported in patients with toxocarosis and ascariasis. Conclusions. In the structure of HBP in children, functional disorders of the biliary tract were prevalent. In HBP and concomitant parasitosis (especially ascariasis and toxocarosis), IL-4 and TNF-α levels are significantly higher in patients without concomitant parasitosis.

Keywords


children; hepatobiliary pathology; interleukin 4; tumor necrosis factor α; parasitosis

References


Lukianenko OYu, Panteleeva TI. Dysfunction of the biliary tract in children: traditional approaches and new postulates. Gastroenterologìa. 2017;51(3):213-221. doi:10.22141/2308 -2097.51.3.2017.112640. (in Ukrainian).

Kosynska SV. Biliary dysfunctions: modern concepts, diagnosis and treatment. Gastroenterologìa. 2014;(51):78-83. doi: 10.22141/2224-551.5.1.73.1.2016.78953. (in Ukrainian).

Haritonova LA, Zaprudnov AM. Diseases of the biliary tract in children - a modern approach to the problem. Pediatria. 2016;95(6):130-139. (in Russian).

Yershova IB, Mochalova HO, Lokhmatova IA, Manashova MH, Petrenko OV. Non-specific manifestations of helminthiasis in children. Zdorov'e rebenka. 2015;(68):45-50. (in Russian).

Glushko KT. Some aspects of diseases of the digestive system in children with concomitant stronhyloidosis. Pediatrija, akusherstvo ta ginekologija. 2014;(2):25-26. (in Ukrainian).

Decker ML, Gotta V, Wellmann S, Ritz N. Cytokine profiling in healthy children shows association of age with cytokine concentrations. Sci Rep. 2017 Dec 19;7(1):17842. doi: 10.1038/s41598-017-17865-2.

Yang WC, Hwang YS, Chen YY, et al. Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells. Front Immunol. 2017 Nov 14;8:1508. doi: 10.3389/fimmu.2017.01508.

Araujo Z, Brandes S, Pinelli E, et al. Seropositivity for ascariosis and toxocariosis and cytokine expression among the indigenous people in the Venezuelan Delta region. Rev Inst Med Trop Sao Paulo. 2015 Jan-Feb;57(1):47-55. doi: 10.1590/S0036-46652015000100007.

Else KJ, Finkelman FD, Maliszewski CR, Grencis RK. Cytokine-mediated regulation of chronic intestinal helminth infection. J Exp Med. 1994 Jan 1;179(1):347-51. doi: 10.1084/jem.179.1.347.

Bol'bot IuK. Helminthiasis in children. Zdorov'e rebenka. 2011;(33):23-26. (in Russian).




DOI: https://doi.org/10.22141/2308-2097.52.1.2018.130776

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